Gonzalez S, von Bassewitz D B, Grundmann E, Nakhosteen J A, Müller K M
Ultrastruct Pathol. 1985;8(4):345-56. doi: 10.3109/01913128509141523.
Twenty-two cases displaying potentially precancerous epithelial changes of the bronchial mucosa--including basal and goblet cell hyperplasia, epidermoid metaplasia, and dysplasia--showed a wide variety of cilial abnormalities on the ultrastructural level. The changes comprised abnormal configurations of the ciliary plasma membrane, variations in the amount of ciliary matrix, disorganization of basal bodies, and diverse alterations of the axonemal microtubular pattern. More than one such alteration was observed in one and the same case, and there was no correlation with the actual type of epithelial lesion nor the degree of dysplasia. These changes, interpreted as abnormal ciliary regeneration in severely damaged ciliated cells, are potentially reversible and seem to represent a nonspecific response of the affected cells to an ample spectrum of noxes. Their diagnostic significance is poor, especially with regard to the modification of the axonemal microtubular pattern, unless the entire clinical picture suggests an immotile cilia syndrome.
22例表现出支气管黏膜潜在癌前上皮改变（包括基底细胞和杯状细胞增生、表皮化生及发育异常）的病例，在超微结构水平显示出多种纤毛异常。这些改变包括纤毛质膜的异常形态、纤毛基质数量的变化、基体的紊乱以及轴丝微管模式的多样改变。在同一病例中观察到不止一种此类改变，且与上皮病变的实际类型及发育异常程度均无关联。这些改变被解释为严重受损纤毛细胞中的异常纤毛再生，具有潜在可逆性，似乎代表了受影响细胞对多种有害因素的非特异性反应。其诊断意义不大，尤其是轴丝微管模式的改变，除非整个临床情况提示纤毛不动综合征。
