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纳米比亚的辅助性伴侣通知服务:新发和既往人类免疫缺陷病毒感染者的病例发现比较,以及作为预防用药转介平台的成效。

Assisted Partner Notification Services in Namibia: Comparison of Case-Finding in Persons With New and Previously Diagnosed Human Immunodeficiency Virus, and Success as a Platform for PrEP Referral.

机构信息

Ministry of Health and Social Services (MHSS), Windhoek, Namibia.

出版信息

Sex Transm Dis. 2024 Mar 1;51(3):214-219. doi: 10.1097/OLQ.0000000000001922. Epub 2024 Jan 3.

DOI:10.1097/OLQ.0000000000001922
PMID:38412468
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10901442/
Abstract

BACKGROUND

Assisted partner notification services (APS) are widely implemented throughout sub-Saharan Africa. The effectiveness of APS among persons with previously diagnosed human immunodeficiency virus (HIV) infection is uncertain, and there are few published data on the success of integrating referrals for HIV preexposure prophylaxis (PrEP) into APS.

METHODS

Staff in 22 Namibian Ministry of Health and Social Service clinics offered APS to patients newly and previously diagnosed with HIV (index cases [ICs]) between October 2019 and June 2021. Counselors used a structured interview guide to elicit ICs' sex partners and biological children and assisted ICs to arrange testing of contacts. Contacts testing HIV-positive were linked to HIV services and those 14 years or older testing negative were offered PrEP. The primary outcome was the case-finding index (contacts testing HIV-positive ÷ ICs receiving APS).

RESULTS

Staff provided APS to 1222 (78%) of 1557 newly diagnosed ICs eliciting 1155 sex partners and 649 biological children. Among 280 previously diagnosed ICs, 279 sex partners and 158 biological children were elicited. The case-finding index was higher among ICs with newly diagnosed HIV compared with previously diagnosed HIV (0.14 vs 0.09, P = 0.46), though this difference was not statistically significant. Most sex partners testing HIV-negative were initiated on PrEP (67% in sex partners from newly diagnosed ICs; 74% in sex partners from previously diagnosed ICs).

CONCLUSIONS

Assisted partner notification services successfully identified sex partners and biological children with undiagnosed HIV infection when provided to both newly and previously diagnosed ICs. Integration of referral to PrEP resulted in many HIV-negative partners initiating PrEP.

摘要

背景

在撒哈拉以南非洲地区,辅助性伴侣通知服务(APS)已广泛实施。针对既往诊断为人免疫缺陷病毒(HIV)感染者的 APS 的有效性尚不确定,并且关于将 HIV 暴露前预防(PrEP)的转诊纳入 APS 的成功数据也很少。

方法

2019 年 10 月至 2021 年 6 月期间,22 家纳米比亚卫生部和社会服务诊所的工作人员为新诊断和既往诊断为 HIV(索引病例[ICs])的患者提供 APS。咨询员使用结构化访谈指南来确定 ICs 的性伴侣和亲生子女,并协助 ICs 安排接触者检测。检测 HIV 阳性的接触者将与 HIV 服务联系,14 岁及以上检测 HIV 阴性的接触者将获得 PrEP。主要结局是病例发现指数(接受 APS 的接触者检测 HIV 阳性人数÷接受 APS 的 IC 人数)。

结果

工作人员为 1557 名新诊断的 IC 中的 1222 名(78%)提供了 APS,共发现 1155 名性伴侣和 649 名亲生子女。在 280 名既往诊断的 IC 中,发现了 279 名性伴侣和 158 名亲生子女。与既往诊断的 HIV 相比,新诊断的 HIV 的病例发现指数更高(0.14 比 0.09,P=0.46),但差异无统计学意义。大多数 HIV 阴性的性伴侣开始接受 PrEP(新诊断的 IC 的性伴侣中为 67%;既往诊断的 IC 的性伴侣中为 74%)。

结论

当为新诊断和既往诊断的 IC 提供辅助性伴侣通知服务时,该服务成功地发现了未被诊断的 HIV 感染的性伴侣和亲生子女。将 PrEP 的转诊纳入其中,导致许多 HIV 阴性的伴侣开始接受 PrEP。