Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, School of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, 712046, Shaanxi, PR China.
School of Public Health, Shaanxi University of Chinese Medicine, Xi'an, 712046, Shaanxi, PR China.
J Ethnopharmacol. 2024 May 23;326:117979. doi: 10.1016/j.jep.2024.117979. Epub 2024 Feb 25.
Mesona chinensis Benth. (or Platostoma palustre (Blume) A. J. Paton) is an important medicinal and edible plant also known as the Hsian-tsao in China and Southeast Asian countries. It is cold in nature and sweet in taste, with the effects of clearing heat, relieving heatstroke and diuretic, and traditionally used to treat heatstroke, erysipelas, hypertension, joint pain and other diseases in folk medicine. It is also a popular supplement with the function of detoxifying and heat-clearing use in Asia. It is used to be processed into the popular tea, Bean jelly, and so on. Published studies have demonstrated that polysaccharides from M. chinensis (MCPs) are one of the principal bioactive ingredients with a variety of health-promoting effects in the prevention and treatment of diseases, including antioxidant, immunomodulation, anti-inflammatory, hepatoprotective, anti-tumor, hypoglycemic, regulation of gut microbiota, and other pharmacological properties.
This review aims to compile the extraction and purification methods, structural characteristics, pharmacological activities including the mechanism of action of MCPs, and to further understand the applications of M. chinensis in order to lay the foundation for the development of MCPs.
By inputting the search term "Mesona chinensis polysaccharides", relevant research information was obtained from databases such as PubMed, Google Scholar, Web of Science, and China National Knowledge Infrastructure (CNKI).
More than 40 polysaccharides have been extracted from M. chinensis, different extraction and purification methods have been described, as well as the structural features and pharmacological activities of MCPs have been systematically reviewed. Polysaccharides, as important components of M. chinensis, were mainly extracted by methods such as hot water dipping method, hot alkali extraction method, enzyme-assisted extraction method and ultrasonic-assisted extraction method, subsequently obtained by decolorization, deproteinization, removal of other small molecules and separation on various chromatographic columns. The chemical composition and structure of MCPs show diversity and have a variety of pharmacological activities, including antioxidant, immunomodulation, anti-inflammatory, hepatoprotective, anti-tumor, hypoglycemic, regulation of gut microbiota, and so on.
This article systematically reviews the research progress of MCPs in terms of extraction and purification, structural characteristics, rheological gel properties, pharmacological properties, and safety assessment. The potentials and roles of M. chinensis in the field of medicine, functional food, and materials are further highlighted to provide references and bases for the high-value processing and utilization of MCPs.
野牡丹（Mesona chinensis Benth.）（或鸭跖草科（Platostoma palustre (Blume) A. J. Paton））是一种重要的药用和食用植物，在中国和东南亚国家也被称为Hsian-tsao。它性凉，味甘，具有清热解暑、利尿的功效，传统上用于治疗中暑、丹毒、高血压、关节痛等民间医学疾病。它也是一种在亚洲流行的解毒和清热补品。它通常被加工成流行的茶、豆腐花等。已发表的研究表明，野牡丹多糖（MCPs）是主要的生物活性成分之一，具有多种促进健康的作用，可预防和治疗疾病，包括抗氧化、免疫调节、抗炎、保肝、抗肿瘤、降血糖、调节肠道微生物群等药理作用。
本综述旨在汇编野牡丹多糖（MCPs）的提取和纯化方法、结构特征、药理活性，包括作用机制，并进一步了解野牡丹的应用，为 MCPs 的开发奠定基础。
通过输入搜索词“野牡丹多糖”，从 PubMed、Google Scholar、Web of Science 和中国国家知识基础设施（CNKI）等数据库中获取相关研究信息。
从野牡丹中已提取出 40 多种多糖，描述了不同的提取和纯化方法，以及 MCPs 的结构特征和药理活性。多糖作为野牡丹的重要成分，主要采用热水浸提法、热碱提取法、酶辅助提取法和超声辅助提取法提取，然后通过脱色、脱蛋白、去除其他小分子和各种色谱柱分离得到。MCPs 的化学成分和结构表现出多样性，具有多种药理活性，包括抗氧化、免疫调节、抗炎、保肝、抗肿瘤、降血糖、调节肠道微生物群等。
本文系统地综述了 MCPs 在提取和纯化、结构特征、流变凝胶特性、药理活性和安全性评价方面的研究进展。进一步强调了野牡丹在医学、功能性食品和材料领域的潜力和作用，为 MCPs 的高值化加工利用提供参考和依据。
