Wang Yuhan, Huang Jie, Zheng Hanhan, Tao Li, Gu Kaiqi, Xie Caihong, Cha Lijun, Chen Hong, Hu Hua
Department of Psychiatry, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Department of Psychiatry, Chongqing Eleventh People's Hospital, Chongqing 400038, China.
J Affect Disord. 2024 May 1;352:509-516. doi: 10.1016/j.jad.2024.02.076. Epub 2024 Feb 25.
Psychological resilience is a protective factor of depression. However, the neuroimaging characteristics of the relationship between psychological resilience and brain imaging in depression are not very clear. Our objectives were to explore the brain functional imaging characteristics of different levels of resilience in female patients with depression.
Resting-state functional magnetic resonance imaging (rs-fMRI) was performed on 58 female depressed patients. According to the resilience score, participants were divided into three groups: Low resilience (Low-res), Medium resilience (Med-res) and High resilience (High-res). We compared the differences in the amplitude of low-frequency fluctuations (ALFF) and functional connectivity (FC) among the three groups and correlated psychological resilience with ALFF and FC.
According to ALFF, there was a higher activation in RI and RPG in the High-res compared with Med-res and Low-res, but no significant differences between Med-res and Low-res. The FC between the RPG and supramarginal gyrus (SG) in the High-res was significantly stronger than that in the Med-res and the Low-res, and the FC of the Med-res is stronger than that of the Low-res. Both ALFF and FC were positively correlated with the score of resilience.
The sample size of this study was relatively small and it lacked healthy controls. The results of this study could be considered preliminary.
Among female patients with depression, patients with higher psychological resilience had higher resting state activation in the RI and RPG and had a stronger interaction between the RPG and the SG.
心理弹性是抑郁症的一个保护因素。然而，抑郁症中心理弹性与脑成像之间关系的神经影像学特征尚不清楚。我们的目的是探讨抑郁症女性患者不同水平心理弹性的脑功能成像特征。
对58名女性抑郁症患者进行静息态功能磁共振成像（rs-fMRI）。根据心理弹性得分，参与者被分为三组：低心理弹性组（Low-res）、中等心理弹性组（Med-res）和高心理弹性组（High-res）。我们比较了三组之间低频振幅（ALFF）和功能连接（FC）的差异，并将心理弹性与ALFF和FC进行了相关性分析。
根据ALFF，高心理弹性组与中等心理弹性组和低心理弹性组相比，右侧岛叶（RI）和右侧顶下小叶（RPG）激活更高，但中等心理弹性组和低心理弹性组之间无显著差异。高心理弹性组中RPG与缘上回（SG）之间的FC显著强于中等心理弹性组和低心理弹性组，中等心理弹性组的FC强于低心理弹性组。ALFF和FC均与心理弹性得分呈正相关。
本研究样本量相对较小且缺乏健康对照。本研究结果可认为是初步的。
在抑郁症女性患者中，心理弹性较高的患者在静息状态下RI和RPG激活较高，且RPG与SG之间的相互作用较强。
