Department of Obstetrics and Gynecology, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Department of Acupuncture and Moxibustion, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Gene. 2024 May 30;909:148314. doi: 10.1016/j.gene.2024.148314. Epub 2024 Feb 25.
The results of studies on the association between polymorphisms in the FSHR gene and the risk of POR undergoing IVF have been inconsistent with each other, so we conducted a meta-analysis of all the available studies to explore the association between polymorphisms in the FSHR gene and the risk of POR.
Literature that met the inclusion criteria was collected by searching six electronic databases and basic data from included studies were extracted. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of association between follicle-stimulating hormone receptor (FSHR) gene polymorphism and poor ovarian response (POR) risk. Begg's and Egger's tests were used to determine whether there was publication bias, and sensitivity analysis and TSA analysis were used to verify the stability and reliability of the results.
We included 24 articles, 22 of which explored rs6166, including 2,206 cases and 3,897 controls. 6 articles explored rs6165, including 444 cases and 875 controls. Under additive, heterozygote, and dominant models, rs6166 was significantly associated with POR (S vs. N: OR = 1.29, 95 % CI = 1.05-1.59, P = 0.017; NS vs. NN: OR = 1.33, 95 % CI = 1.02-1.74, P = 0.038; NS + SS vs. NN: OR = 1.38, 95 % CI = 1.04-1.84, P = 0.025). In ethnicity-based subgroup analyses, the additive, homozygote, heterozygote, and dominant models increased Asian POR risk. Among the five genetic models, rs6165 was significantly associated with POR (T vs. C: OR = 1.64, 95 % CI = 1.25-2.16, P = 0.000; TT vs. CC: OR = 2.76, 95 % CI = 1.43-5.32, P = 0.003; CT vs. CC: OR = 1.58, 95 % CI = 1.19-2.10, P = 0.001; TT vs. CC + CT: OR = 2.32, 95 % CI = 1.67-3.23, P = 0.000; CT + TT vs. CC: OR = 1.80, 95 % CI = 1.22-2.65, P = 0.003). In ethnicity-based subgroup analyses, all five genetic models increased the risk of POR in Caucasians.
According to the current meta-analysis, the rs6166 S allele was significantly associated with an increased risk of POR, especially in Asian populations. The rs6165 T allele was significantly associated with an increased risk of POR, especially in Caucasian populations.
关于 FSHR 基因多态性与接受 IVF 的 POR 风险之间的关联的研究结果相互不一致，因此我们进行了荟萃分析，以探讨 FSHR 基因多态性与 POR 风险之间的关联。
通过搜索六个电子数据库来收集符合纳入标准的文献，并提取纳入研究的基本数据。使用比值比（OR）和 95%置信区间（CI）来评估卵泡刺激素受体（FSHR）基因多态性与卵巢反应不良（POR）风险之间的关联强度。使用 Begg 和 Egger 检验来确定是否存在发表偏倚，并使用敏感性分析和 TSA 分析来验证结果的稳定性和可靠性。
我们纳入了 24 篇文章，其中 22 篇探讨了 rs6166，包括 2206 例病例和 3897 例对照。6 篇文章探讨了 rs6165，包括 444 例病例和 875 例对照。在加性、杂合子和显性模型下，rs6166 与 POR 显著相关（S 与 N：OR=1.29，95%CI=1.05-1.59，P=0.017；NS 与 NN：OR=1.33，95%CI=1.02-1.74，P=0.038；NS+SS 与 NN：OR=1.38，95%CI=1.04-1.84，P=0.025）。基于种族的亚组分析中，加性、纯合子、杂合子和显性模型均增加了亚洲 POR 风险。在五种遗传模型中，rs6165 与 POR 显著相关（T 与 C：OR=1.64，95%CI=1.25-2.16，P=0.000；TT 与 CC：OR=2.76，95%CI=1.43-5.32，P=0.003；CT 与 CC：OR=1.58，95%CI=1.19-2.10，P=0.001；TT 与 CC+CT：OR=2.32，95%CI=1.67-3.23，P=0.000；CT+TT 与 CC：OR=1.80，95%CI=1.22-2.65，P=0.003）。基于种族的亚组分析中，五种遗传模型均增加了高加索人群 POR 的风险。
根据当前的荟萃分析，rs6166 的 S 等位基因与 POR 风险增加显著相关，尤其是在亚洲人群中。rs6165 的 T 等位基因与 POR 风险增加显著相关，尤其是在高加索人群中。
