Chen X, Huang L, Yu W, He W, Li T, Liu Y
Sichuan Provincial Center for Disease Control and Prevention, Chengdu, Sichuan 610041, China.
Co-first authors.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2024 Jan 30;35(6):633-637. doi: 10.16250/j.32.1374.2023130.
To investigate the prevalence and epidemiological characteristics of taeniasis and cysticercosis among residents in Tibetan agricultural areas of Sichuan Province, so as to provide insights for the prevention and control of taeniasis and cysticercosis.
From 2016 to 2022, Kangding City, Daocheng County, Derong County, Ruoergai County and Muli Tibetan Autonomous County were sampled from Tibetan agricultural areas of Ganzi Tibetan Autonomous Prefecture, Aba Tibetan and Qiang Autonomous Prefecture and Liangshan Yi Autonomous Prefecture in Sichuan Province, and 1 to 6 townships were sampled from each county (district), followed by 4 to 7 villages sampled from each township. Primary school children were sampled using a cluster sampling method, and permanent residents at ages of over 16 years were randomly sampled from each village. Participants' demographics, history of tapeworm excretion during the past year and clinical symptoms and signs of cysticercosis were collected through questionnaire surveys, and participants' stool and venous blood samples were collected. eggs were detected in stool samples using the direct smear method, and deworming was performed among taeniasis patients with areca nut-squash seeds. The tapeworm species were identified using a multiplex PCR assay, and serum specific IgG antibody against cysticercus was detected using enzyme-linked immunosorbent assay (ELISA).
A total of 5 249 respondents participated in the questionnaire survey, including 603 respondents (11.5%) with a self-reported history of proglottids secretion during the past year. A total of 3 976 residents were subjected to stool examinations, and the detection of eggs was 6.5%. Of 258 participants undergoing deworming, there were 403 cases (94.2%) with excretions of worms or proglottids. The mean prevalence of taeniasis was 10.9% (439/4 043), and there were gender-, age- and region-specific prevalence rates of taeniasis (χ = 36.73, 126.31 and 163.41, all values < 0.05). Multiplex PCR assays detected 41 cases with infections (12.5%), 197 cases with infections (59.9%) and 91 cases with infections (27.6%) among 329 patients undergoing deworming, and there were region-specific prevalence rates of , and infections (χ = 45.39, < 0.05). In addition, the sero-prevalence of anti-cysticercus IgG antibody was 7.0% (345/4 933), and there were age- and region-specific sero-prevalence rates of anti-cysticercus IgG antibody (χ = 13.49 and 51.76, both values < 0.05).
Multiple species are prevalent in Tibetan agricultural areas of Sichuan Province and the sero-prevalence of anti-cysticercus antibody is high among residents. Monitoring and control of taeniasis and cysticercosis should be strengthened.
调查四川省藏族农区居民带绦虫病和囊尾蚴病的流行现状及流行病学特征，为带绦虫病和囊尾蚴病的防治提供依据。
2016年至2022年，选取四川省甘孜藏族自治州、阿坝藏族羌族自治州和凉山彝族自治州藏族农区的康定市、稻城县、得荣县、若尔盖县和木里藏族自治县，每个县（区）抽取1至6个乡，再从每个乡抽取4至7个村。采用整群抽样方法抽取小学生，从每个村随机抽取16岁以上常住人口。通过问卷调查收集参与者的人口学资料、过去一年排绦虫节片史及囊尾蚴病临床症状和体征，并采集参与者的粪便和静脉血样本。粪便样本采用直接涂片法检测虫卵，对带绦虫病患者用槟榔南瓜子进行驱虫治疗。采用多重聚合酶链反应（PCR）法鉴定绦虫种类，用酶联免疫吸附试验（ELISA）检测血清抗囊尾蚴特异性IgG抗体。
共5 249名受访者参与问卷调查，其中603名（11.5%）自述过去一年有排绦虫节片史。共3 976名居民接受粪便检查，虫卵检出率为6.5%。258名接受驱虫治疗的参与者中，有403例（94.2%）排出虫体或绦虫节片。带绦虫病的平均患病率为10.9%（439/4 043），带绦虫病患病率存在性别、年龄和地区差异（χ² = 36.73、126.31和163.41，P值均<0.05）。在329例接受驱虫治疗的患者中，多重PCR法检测出41例（12.5%）感染微小膜壳绦虫、197例（59.9%）感染猪带绦虫、91例（27.6%）感染牛带绦虫，微小膜壳绦虫、猪带绦虫和牛带绦虫感染率存在地区差异（χ² = 45.39，P<0.05）。此外，抗囊尾蚴IgG抗体血清阳性率为7.0%（345/4 933），抗囊尾蚴IgG抗体血清阳性率存在年龄和地区差异（χ² = 13.49和51.76，P值均<0.05）。
四川省藏族农区多种绦虫种类流行，居民抗囊尾蚴抗体血清阳性率高，应加强带绦虫病和囊尾蚴病的监测与防控。
