Aun C, Thomas D, St John-Jones L, Colvin M P, Savege T M, Lewis C T
Eur J Anaesthesiol. 1985 Dec;2(4):419-26.
The effects of intrathecal morphine in 60 patients undergoing open-heart surgery were studied in an observer-blind control trial. The patients were randomly allocated into three groups of 20 each: (A) Control, (B) 2 mg and (C) 4 mg of intrathecal morphine. This study confirms that intrathecal morphine provides useful post-operative analgesia. Patients given intrathecal morphine required less postoperative analgesia and sedation and their respiratory function tests were less depressed than the control group. Since the completion of this study, reports have suggested that 1 mg of morphine intrathecally avoids the serious complications of respiratory depression. In the study described, the patients were electively ventilated post-operatively and respiratory depression was therefore not a problem. Of the other associated side-effects of intrathecal morphine, vomiting (20%) and pruritus (20%) proved the most troublesome.
在一项观察者盲法对照试验中，研究了鞘内注射吗啡对60例接受心脏直视手术患者的影响。患者被随机分为三组，每组20人：(A)对照组、(B)鞘内注射2毫克吗啡组和(C)鞘内注射4毫克吗啡组。本研究证实鞘内注射吗啡可提供有效的术后镇痛。接受鞘内注射吗啡的患者术后所需的镇痛和镇静较少，其呼吸功能测试的受抑制程度也低于对照组。自本研究完成以来，有报告表明鞘内注射1毫克吗啡可避免呼吸抑制的严重并发症。在所描述的研究中，患者术后接受选择性通气，因此呼吸抑制不是问题。鞘内注射吗啡的其他相关副作用中，呕吐(20%)和瘙痒(20%)被证明是最麻烦的。
