Department of Pharmaceutics, School of Pharmacy, Faculty of Pharmacy, and Research & Development Cell, Parul University, Waghodia, Vadodara, 391760, Gujarat, India.
Department of Pharmaceutics, Krishna School of Pharmacy & Research, Drs. Kiran and Pallavi Patel Global University, Vadodara, 391243, Gujarat, India.
AAPS PharmSciTech. 2024 Feb 27;25(3):46. doi: 10.1208/s12249-024-02763-4.
Novel formulations are developed for dermatological applications to address a wide range of patient needs and therapeutic challenges. By pushing the limits of pharmaceutical technology, these formulations strive to provide safer, more effective, and patient-friendly solutions for dermatological concerns, ultimately improving the overall quality of dermatological care. The article explores the different types of novel dermatological formulations, including nanocarriers, transdermal patches, microsponges, and microneedles, and the techniques involved in the cutaneous pharmacokinetics of these innovative formulations. Furthermore, the significance of knowing cutaneous pharmacokinetics and the difficulties faced during pharmacokinetic assessment have been emphasized. The article examines all the methods employed for the pharmacokinetic evaluation of novel dermatological formulations. In addition to a concise overview of earlier techniques, discussions on novel methodologies, including tape stripping, in vitro permeation testing, cutaneous microdialysis, confocal Raman microscopy, and matrix-assisted laser desorption/ionization mass spectrometry have been conducted. Emerging technologies like the use of microfluidic devices for skin absorption studies and computational models for predicting drug pharmacokinetics have also been discussed. This article serves as a valuable resource for researchers, scientists, and pharmaceutical professionals determined to enhance the development and understanding of novel dermatological drug products and the complex dynamics of cutaneous pharmacokinetics.
新型制剂被开发用于皮肤科应用，以满足广泛的患者需求和治疗挑战。通过推动药物技术的极限，这些制剂努力为皮肤科问题提供更安全、更有效、更适合患者的解决方案，最终提高皮肤科护理的整体质量。本文探讨了不同类型的新型皮肤科制剂，包括纳米载体、透皮贴剂、微海绵和微针，以及这些创新制剂的皮肤药代动力学所涉及的技术。此外，还强调了了解皮肤药代动力学和在药代动力学评估中面临的困难的重要性。本文还研究了用于评估新型皮肤科制剂药代动力学的所有方法。除了对早期技术的简要概述外，还讨论了包括胶带剥离、体外渗透测试、皮肤微透析、共聚焦拉曼显微镜和基质辅助激光解吸/电离质谱在内的新型方法。还讨论了一些新兴技术，例如微流控装置在皮肤吸收研究中的应用以及用于预测药物药代动力学的计算模型。本文为研究人员、科学家和制药专业人员提供了有价值的资源，有助于促进新型皮肤科药物产品的开发和理解以及皮肤药代动力学的复杂动态。
