病例报告：药物遗传学评估提示的危及生命的氟西汀相关性术后出血
Case Report: Life-Threatening Fluoxetine-Linked Postoperative Bleeding Informed by Pharmacogenetic Evaluation.
作者信息
Rogers Sara, Silva Patrick J, Udeani George, Deleon Monica, Mutyala Sriarchala, Panahi Ladan, Abu-Baker Asim, Neal Gabriel, Ramos Kenneth S
机构信息
Department of Pharmacy Practice, Irma Lerma Rangel School of Pharmacy, Texas A&M University, Kingsville, TX, 78363, USA.
Department of Translational Medical Sciences, School of Medicine, Texas A&M Health Science Center, Bryan, TX, 77807, USA.
出版信息
Drugs R D. 2024 Mar;24(1):117-121. doi: 10.1007/s40268-023-00451-5. Epub 2024 Feb 28.
Abstract
BACKGROUND
Selective serotonin reuptake inhibitors (SSRI) are commonly used for the treatment of depression and anxiety. Inhibition of serotonin reuptake in platelets increases bleeding risk in patients taking SSRIs.
CASE
Here, we present the case of a 52-year-old patient who developed severe postsurgical bleeding requiring blood transfusion following panniculectomy.
CONCLUSION
SSRI-induced bleeding is dose-related and strongly influenced by individual variations in drug metabolizing enzymes and transporters. Supplementary file1 (MP4 8441 KB).
摘要
背景
选择性5-羟色胺再摄取抑制剂（SSRI）常用于治疗抑郁症和焦虑症。服用SSRI的患者，血小板中5-羟色胺再摄取受抑制会增加出血风险。
病例
在此，我们报告一例52岁患者，其在腹部去脂术后发生严重术后出血，需要输血。
结论
SSRI引起的出血与剂量相关，且受药物代谢酶和转运体个体差异的强烈影响。补充文件1（MP4格式，8441KB）。
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