禽胰多肽、神经肽Y和去甲肾上腺素对大鼠视上核加压素神经元兴奋性作用的比较。

Comparison between the actions of avian pancreatic polypeptide, neuropeptide Y and norepinephrine on the excitability of rat supraoptic vasopressin neurons.

作者信息

Day T A, Jhamandas J H, Renaud L P

出版信息

Neurosci Lett. 1985 Dec 4;62(2):181-5. doi: 10.1016/0304-3940(85)90352-0.

Abstract

Effects of pressure-applied avian pancreatic polypeptide (APP), neuropeptide Y (NPY) and norepinephrine (NE) on the activity of putative vasopressin-synthesizing neurosecretory cells of the supraoptic nucleus were studied in pentobarbitone-anesthetized male rats. APP (17-170 microM) excited 80% (20/25), NPY (20 microM-2 mM) excited 23% (6/26) and NE (100-200 microM) excited 76% (26/34) of cells tested; no depressant actions were observed. However, simultaneously applied APP appeared to reduce the NE-evoked excitation in 4/4 cells tested. These data indicate that an endogenous pancreatic polypeptide-like peptide may mimic the excitatory actions of NE on supraoptic vasopressin-synthesizing neurosecretory cells but only at high concentrations. These peptides do not potentiate but rather appear to interfere with NE's excitatory effects.

摘要

在戊巴比妥麻醉的雄性大鼠中，研究了加压应用禽胰多肽（APP）、神经肽Y（NPY）和去甲肾上腺素（NE）对视上核假定的血管加压素合成神经分泌细胞活性的影响。APP（17 - 170微摩尔）使80%（20/25）的受试细胞兴奋，NPY（20微摩尔 - 2毫摩尔）使23%（6/26）的受试细胞兴奋，NE（100 - 200微摩尔）使76%（26/34）的受试细胞兴奋；未观察到抑制作用。然而，同时应用APP似乎使4/4的受试细胞中NE诱发的兴奋作用减弱。这些数据表明，一种内源性胰多肽样肽可能模拟NE对视上核血管加压素合成神经分泌细胞的兴奋作用，但仅在高浓度时。这些肽不会增强而是似乎会干扰NE的兴奋作用。