中风后认知功能下降的危险因素及预测标志物——一篇综述
Risk factors and predictive markers of post-stroke cognitive decline-A mini review.
作者信息
Guo Xiaofan, Phan Cattien, Batarseh Sanad, Wei Miao, Dye Justin
机构信息
Department of Neurology, Loma Linda University, Loma Linda, CA, United States.
Department of Neurosurgery, Loma Linda University, Loma Linda, CA, United States.
出版信息
Front Aging Neurosci. 2024 Feb 13;16:1359792. doi: 10.3389/fnagi.2024.1359792. eCollection 2024.
Abstract
Stroke is one of the top causes of death and disability worldwide. Cognitive impairments are found in more than 70% of individuals who have survived a stroke. Cognitive decline is a major contributor to disability, dependency, and morbidity. The prevalence and severity of dementia vary depending on different characteristics of the stroke and other clinical risk factors. Here we discuss the effects of stroke territory, patients' age, sex, cerebral blood flow, acute reperfusion therapy, and cognitive reserve of post-stroke cognitive decline. Potential predictive molecular and genetic biomarkers of post-stroke cognitive impairments are also discussed.
摘要
中风是全球范围内导致死亡和残疾的主要原因之一。超过70%的中风幸存者存在认知障碍。认知衰退是导致残疾、依赖和发病的主要因素。痴呆症的患病率和严重程度因中风的不同特征及其他临床风险因素而异。在此，我们讨论中风区域、患者年龄、性别、脑血流量、急性再灌注治疗以及中风后认知衰退的认知储备的影响。还讨论了中风后认知障碍潜在的预测性分子和遗传生物标志物。
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