Baidya Sujata, Tuladhar Eans Tara, Sharma Vijay Kumar, Dubey Raju Kumar, Raut Mithileshwer, Bhattarai Aseem, Parajuli Naresh, Niraula Apeksha
Department of Clinical Biochemistry, Institute of Medicine, Maharajgunj Medical Campus, Tribhuvan University, Kathmandu 44600, Nepal.
Department of Internal Medicine (Endocrinology), Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu 44600, Nepal.
J Endocr Soc. 2024 Feb 20;8(4):bvad143. doi: 10.1210/jendso/bvad143. eCollection 2024 Feb 19.
Vitamin D deficiency is a global public health concern that provokes bone demineralization and weakening. In response to the decreased vitamin D level, calcium stores wear out. The homeostatic effect of compensatory hyperparathyroidism in vitamin D deficiency incites variable discrepancies in different populations. This study intends to decipher the transition point of PTH in relation to levels of vitamin D in a Nepalese population. A cross-sectional study was carried out at Tribhuvan University Teaching Hospital, Nepal. Serum calcium, phosphorus, intact PTH, and 25-hydroxy vitamin D levels were assayed in an Abbott ARCHITECT Integrated System. A correlation plot of PTH and vitamin D was analyzed in Statistical Package for Social Sciences version 22.0. Using a locally weighted scatter plot smoothing method, the relation between these variables was presented graphically. Among 281 individuals, 30.2% had vitamin D levels below 20 ng/mL. There was an archetypical transition in the PTH levels in concert with the decrease in vitamin D level marked by 2 inflection points (ie, 18.5 and 42.0 ng/mL). Our findings suggest that to augment overall health and avert weakness due to vitamin D deficiency, the levels of vitamin D should be maintained above 42.0 ng/mL in our population.
维生素D缺乏是一个全球性的公共卫生问题，会引发骨质脱矿和骨质变弱。为应对维生素D水平下降，钙储备会耗尽。维生素D缺乏时代偿性甲状旁腺功能亢进的稳态效应在不同人群中引发了不同程度的差异。本研究旨在解读尼泊尔人群中甲状旁腺激素（PTH）与维生素D水平相关的转变点。在尼泊尔的特里布万大学教学医院开展了一项横断面研究。在雅培ARCHITECT综合系统中检测血清钙、磷、完整PTH和25-羟基维生素D水平。在社会科学统计软件包第22.0版中分析PTH与维生素D的相关图。使用局部加权散点图平滑方法，以图形方式展示这些变量之间的关系。在281名个体中，30.2%的维生素D水平低于20 ng/mL。随着维生素D水平下降，PTH水平出现典型转变，有2个拐点（即18.5和42.0 ng/mL）。我们的研究结果表明，为增强整体健康并避免因维生素D缺乏导致的身体虚弱，在我们的人群中维生素D水平应维持在42.0 ng/mL以上。
