Jhaveri Tulip A, Weiss Zoe Freeman, Winkler Marisa L, Pyden Alexander D, Basu Sankha S, Pecora Nicole D
Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS, USA.
Division of Pathology and Laboratory Medicine, Tufts Medical Center, Boston, MA, USA.
Antimicrob Steward Healthc Epidemiol. 2024 Jan 25;4(1):e8. doi: 10.1017/ash.2024.10. eCollection 2024.
The past 10 years have brought paradigm-shifting changes to clinical microbiology. This paper explores the top 10 transformative innovations across the diagnostic spectrum, including not only state of the art technologies but also preanalytic and post-analytic advances. Clinical decision support tools have reshaped testing practices, curbing unnecessary tests. Innovations like broad-range polymerase chain reaction and metagenomic sequencing, whole genome sequencing, multiplex molecular panels, rapid phenotypic susceptibility testing, and matrix-assisted laser desorption ionization time-of-flight mass spectrometry have all expanded our diagnostic armamentarium. Rapid home-based testing has made diagnostic testing more accessible than ever. Enhancements to clinician-laboratory interfaces allow for automated stewardship interventions and education. Laboratory restructuring and consolidation efforts are reshaping the field of microbiology, presenting both opportunities and challenges for the future of clinical microbiology laboratories. Here, we review key innovations of the last decade.
过去十年给临床微生物学带来了范式转变的变化。本文探讨了诊断领域的十大变革性创新，不仅包括最先进的技术，还包括分析前和分析后的进展。临床决策支持工具重塑了检测实践，减少了不必要的检测。诸如广谱聚合酶链反应和宏基因组测序、全基因组测序、多重分子检测板、快速表型药敏试验以及基质辅助激光解吸电离飞行时间质谱等创新，都扩展了我们的诊断手段。基于家庭的快速检测使诊断检测比以往任何时候都更容易获得。临床医生与实验室界面的改进允许进行自动化管理干预和教育。实验室的重组和整合努力正在重塑微生物学领域，为临床微生物学实验室的未来带来了机遇和挑战。在此，我们回顾过去十年的关键创新。
