An Zhenyu, Miao Man, Sun Fengkai, Lan Xiao-Bing, Yu Jian-Qiang, Guo Xiaoli, Zhang Jian
College of Pharmacy, Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
Medicinal Chemistry and Bioinformatics Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Org Biomol Chem. 2024 Mar 20;22(12):2370-2374. doi: 10.1039/d3ob01934a.
An efficient method was developed for the one-pot construction of pyrrolo[1,2-]quinoxalines a Cu(II)-catalyzed domino reaction between 2-(1-pyrrol-1-yl)anilines and alkylsilyl peroxides. This reaction proceeds through C-C bond cleavage and new C-C and C-N bond formation. A mechanistic study suggests that alkyl radical species participate in the cascade reaction.
开发了一种高效的一锅法构建吡咯并[1,2 - ]喹喔啉的方法，该方法是2-(1 - 吡咯 - 1 - 基)苯胺与烷基甲硅烷基过氧化物之间的铜(II)催化多米诺反应。该反应通过C - C键断裂以及新的C - C和C - N键形成来进行。机理研究表明烷基自由基物种参与了该串联反应。
