Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.
J Pediatric Infect Dis Soc. 2024 Feb 28;13(Supplement_1):S22-S30. doi: 10.1093/jpids/piae005.
Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in pediatric transplantation. However, currently utilized CMV prevention paradigms have limitations, leading to research aimed at novel strategies for mitigation of CMV infection. Cell-mediated immunity (CMI) is crucial in controlling CMV infection and the use of CMV-specific CMI assays to guide prevention and treatment of CMV infection in both solid organ transplant and hematopoietic cell transplant recipients shows great promise. In this article, we review the immune response to CMV infection to highlight the rationale for CMI assays, describe available commercial assays and strategies for their use, and summarize relevant literature regarding the use of CMI assays in transplant recipients.
巨细胞病毒（CMV）是儿科移植中发病率和死亡率的重要原因。然而，目前使用的 CMV 预防模式存在局限性，因此需要研究新的策略来减轻 CMV 感染。细胞介导的免疫（CMI）对于控制 CMV 感染至关重要，使用 CMV 特异性 CMI 检测来指导实体器官移植和造血细胞移植受者的 CMV 感染的预防和治疗具有很大的潜力。本文综述了 CMV 感染的免疫反应，以强调 CMI 检测的基本原理，描述了现有的商业检测及其使用策略，并总结了关于 CMI 检测在移植受者中应用的相关文献。
