Fujimoto S, Makinoda S, Tanaka T, Ichinohe K
Jpn J Antibiot. 1985 Dec;38(12):3513-9.
Clinical effect in obstetrics and gynecology was studied on aztreonam (AZT), a potent monobactam antibiotic for Gram-negative bacteria. AZT was tested for 7 cases and effective for all of them with quite a high effective rate of 100%. Neither side effect nor abnormal laboratory findings were noted and it sufficiently proves the property of AZT, a totally chemical-synthesized product with lower incidence of allergic reaction. The above results suggest that AZT is useful for obstetrics and gynecologic infections in view of its high stability to beta-lactamase and dehydropeptidase and high potency against Gram-negative bacteria.
对氨曲南(AZT)这一强效抗革兰氏阴性菌单环β-内酰胺类抗生素在妇产科的临床疗效进行了研究。对7例患者使用了氨曲南,所有患者均有效,有效率高达100%。未观察到副作用及实验室检查异常,充分证明了氨曲南这一完全化学合成产品过敏反应发生率较低的特性。上述结果表明,鉴于氨曲南对β-内酰胺酶和脱氢肽酶具有高度稳定性且对革兰氏阴性菌有高效力,它对妇产科感染有用。