Faculty of Pharmaceutical Sciences, University of Toyama.
Chem Pharm Bull (Tokyo). 2024;72(2):234-239. doi: 10.1248/cpb.c23-00887.
The first lactam-type 2-iodobenzamide catalysts, 8-iodoisoquinolinones 8 (IB-lactam) and 9 (MeO-IB-lactam), were developed. These catalysts have a conformationally rigid 6/6 bicyclic lactam structure and are more reactive than the previously reported catalysts 2-iodobenzamides 4 (IBamide) and 5 (MeO-IBamide) for the oxidation of alcohols. The lactam structure could form an efficient intramolecular I---O interaction, depending on the size of the lactam ring.
首次开发了 2-卤代苯甲酰胺类的第一种酰胺环型催化剂 8-碘异喹啉酮 8（IB-酰胺环）和 9（MeO-IB-酰胺环）。与之前报道的催化剂 2-卤代苯甲酰胺 4（IBamide）和 5（MeO-IBamide）相比，这些催化剂具有构象刚性的 6/6 双环酰胺结构，对于醇的氧化反应具有更高的活性。酰胺环结构可以根据酰胺环的大小形成有效的分子内 I---O 相互作用。
