Endeavor Health, Glenview, Illinois, USA.
Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.
J Am Coll Cardiol. 2024 Mar 5;83(9):932-950. doi: 10.1016/j.jacc.2023.12.033.
Atrial fibrillation (AF) and heart failure (HF) are common cardiovascular conditions that frequently coexist. Among patients with HF, more than one-half also have AF. Both are associated with significant morbidity and mortality. Moreover, the prevalence of each is increasing globally, and this trend is expected to continue owing to an aging population and increased life expectancy. Diagnosis of AF in a patient with HF is associated with greater symptom burden, more frequent hospitalizations, and a worse prognosis. Guideline-directed medical therapy (GDMT) for HF can affect the incidence of AF. Once present, AF can influence the efficacy of some components of GDMT for HF. In this review, we discuss the effect of GDMT for HF across the spectrum of ejection fraction on prevention of AF as well as the benefit of GDMT in patients with vs without AF.
心房颤动（AF）和心力衰竭（HF）是常见的心血管疾病，常同时存在。在 HF 患者中，超过一半的患者也有 AF。两者都与显著的发病率和死亡率相关。此外，由于人口老龄化和预期寿命的延长，每种疾病的患病率都在全球范围内增加，这种趋势预计还将持续。HF 患者的 AF 诊断与更大的症状负担、更频繁的住院治疗和更差的预后相关。HF 的指南指导的药物治疗（GDMT）可影响 AF 的发生率。一旦出现，AF 可能会影响 HF 的某些 GDMT 成分的疗效。在这篇综述中，我们讨论了 GDMT 在射血分数谱中对预防 AF 的影响，以及 GDMT 在有或没有 AF 的患者中的获益。
