Department of Internal Medicine, Northwest General Hospital and Research Center, Peshawar, Pakistan.
FDepartment of Internal Medicine, Northwest General Hospital and Research Center, Peshawar, Pakistan.
J Pak Med Assoc. 2024 Feb;74(2):272-276. doi: 10.47391/JPMA.8474.
To determine the effects of granulocyte colony-stimulating factor in improving platelet count in patients with dengue fever.
The retrospective, cross-sectional study was conducted at Northwest General Hospital and Research Centre, Peshawar, Pakistan, between January 2021 and October 2022, and comprised dengue fever inpatients regardless of age and gender who received granulocyte colony-stimulating factor subcutaneously. The impact of colony-stimulating factor on platelet and white blood cell counts as well as any unfavourable consequences was assessed. Convenient sampling was used and a structured format was used for data collection. Data was analysed using SPSS 21.
Of the 100 patients, 67(67%) were males and 33(33%) were females. The largest age group was that of >55 years 31(31%), fever was present in all the 100(100%) cases, bleeding in 18(18%) and platelet count <30,000 in 83(83%) cases. Dengue fever was confirmed by rapid dengue nonstructural protein 1 antigen in 76(76%) cases, dengue immunoglobulin G antibody test 28(28%), and immunoglobulin M antibody test in 31(31%) cases. Overall, 72(72%) patients received only one dose of granulocyte colony-stimulating factor. Post-administration, a substantial rise in the median platelet and white blood cell counts was seen compared to the baseline (p<0.05) on day 2.
Granulocyte colony-stimulating factor helped increase platelet and white blood cell counts quickly in dengue fever patients.
评估粒细胞集落刺激因子在提高登革热患者血小板计数方面的效果。
本回顾性、横断面研究于 2021 年 1 月至 2022 年 10 月在巴基斯坦白沙瓦的西北综合医院和研究中心进行，纳入接受皮下注射粒细胞集落刺激因子的登革热住院患者，无论年龄和性别。评估集落刺激因子对血小板和白细胞计数的影响以及任何不良后果。采用方便抽样，使用结构化格式收集数据。使用 SPSS 21 对数据进行分析。
在 100 例患者中，67 例（67%）为男性，33 例（33%）为女性。年龄最大的是>55 岁组，有 31 例（31%）；100 例患者均有发热，18 例（18%）有出血，83 例（83%）血小板计数<30,000。76 例（76%）患者通过快速登革热非结构蛋白 1 抗原、28 例（28%）登革热免疫球蛋白 G 抗体试验和 31 例（31%）免疫球蛋白 M 抗体试验确诊登革热。总体而言，72 例（72%）患者仅接受了 1 次粒细胞集落刺激因子治疗。与基线相比，第 2 天血小板和白细胞计数的中位数显著升高（p<0.05）。
粒细胞集落刺激因子有助于快速提高登革热患者的血小板和白细胞计数。
