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脑出血中的星形胶质细胞:影响与治疗目标

Astrocytes in intracerebral hemorrhage: impact and therapeutic objectives.

作者信息

Dong Hao, Wen Xin, Zhang Bai-Wen, Wu Zhe, Zou Wei

机构信息

The First Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, China.

The Third Department of Acupuncture and Moxibustion, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.

出版信息

Front Mol Neurosci. 2024 Feb 14;17:1327472. doi: 10.3389/fnmol.2024.1327472. eCollection 2024.

Abstract

Intracerebral hemorrhage (ICH) manifests precipitously and profoundly impairs the neurological function in patients who are affected. The etiology of subsequent injury post-ICH is multifaceted, characterized by the intricate interplay of various factors, rendering therapeutic interventions challenging. Astrocytes, a distinct class of glial cells, interact with neurons and microglia, and are implicated in a series of pathophysiological alterations following ICH. A comprehensive examination of the functions and mechanisms associated with astrocytic proteins may shed light on the role of astrocytes in ICH pathology and proffer innovative therapeutic avenues for ICH management.

摘要

脑出血(ICH)发病急骤,严重损害患者的神经功能。脑出血后后续损伤的病因是多方面的,其特点是各种因素之间复杂的相互作用,这使得治疗干预具有挑战性。星形胶质细胞是一类独特的神经胶质细胞,与神经元和小胶质细胞相互作用,并参与脑出血后的一系列病理生理改变。全面研究与星形胶质细胞蛋白相关的功能和机制,可能有助于揭示星形胶质细胞在脑出血病理中的作用,并为脑出血的治疗提供创新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9955/10899346/85c9377fa60c/fnmol-17-1327472-g0001.jpg

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