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脑出血中的星形胶质细胞：影响与治疗目标

Astrocytes in intracerebral hemorrhage: impact and therapeutic objectives.

作者信息

Dong Hao, Wen Xin, Zhang Bai-Wen, Wu Zhe, Zou Wei

机构信息

The First Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, China.

The Third Department of Acupuncture and Moxibustion, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.

出版信息

Front Mol Neurosci. 2024 Feb 14;17:1327472. doi: 10.3389/fnmol.2024.1327472. eCollection 2024.

DOI:10.3389/fnmol.2024.1327472
PMID:38419793
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10899346/
Abstract

Intracerebral hemorrhage (ICH) manifests precipitously and profoundly impairs the neurological function in patients who are affected. The etiology of subsequent injury post-ICH is multifaceted, characterized by the intricate interplay of various factors, rendering therapeutic interventions challenging. Astrocytes, a distinct class of glial cells, interact with neurons and microglia, and are implicated in a series of pathophysiological alterations following ICH. A comprehensive examination of the functions and mechanisms associated with astrocytic proteins may shed light on the role of astrocytes in ICH pathology and proffer innovative therapeutic avenues for ICH management.

摘要

脑出血（ICH）发病急骤，严重损害患者的神经功能。脑出血后后续损伤的病因是多方面的，其特点是各种因素之间复杂的相互作用，这使得治疗干预具有挑战性。星形胶质细胞是一类独特的神经胶质细胞，与神经元和小胶质细胞相互作用，并参与脑出血后的一系列病理生理改变。全面研究与星形胶质细胞蛋白相关的功能和机制，可能有助于揭示星形胶质细胞在脑出血病理中的作用，并为脑出血的治疗提供创新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9955/10899346/85c9377fa60c/fnmol-17-1327472-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9955/10899346/85c9377fa60c/fnmol-17-1327472-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9955/10899346/85c9377fa60c/fnmol-17-1327472-g0001.jpg

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本文引用的文献

1
Ion Channel Dysregulation Following Intracerebral Hemorrhage.脑出血后的离子通道失调。
Neurosci Bull. 2024 Mar;40(3):401-414. doi: 10.1007/s12264-023-01118-6. Epub 2023 Sep 27.
2
Association of lactate-to-albumin ratio with in-hospital and intensive care unit mortality in patients with intracerebral hemorrhage.脑出血患者乳酸与白蛋白比值与住院及重症监护病房死亡率的相关性
Front Neurol. 2023 Jul 13;14:1198741. doi: 10.3389/fneur.2023.1198741. eCollection 2023.
3
Roles of neuropathology-associated reactive astrocytes: a systematic review.
神经病理学相关反应性星形胶质细胞的作用：系统评价。
Acta Neuropathol Commun. 2023 Mar 13;11(1):42. doi: 10.1186/s40478-023-01526-9.
4
Knockout of transient receptor potential ankyrin 1 (TRPA1) modulates the glial phenotype and alleviates perihematomal neuroinflammation after intracerebral hemorrhage in mice via MAPK/NF-κB signaling.敲除瞬时受体电位锚蛋白 1（TRPA1）通过 MAPK/NF-κB 信号通路调节脑血肿周围神经胶质细胞表型并减轻神经炎症反应。
Neuroreport. 2023 Feb 1;34(2):81-92. doi: 10.1097/WNR.0000000000001862. Epub 2022 Nov 30.
5
Brain edema formation and therapy after intracerebral hemorrhage.脑出血后脑水肿的形成与治疗。
Neurobiol Dis. 2023 Jan;176:105948. doi: 10.1016/j.nbd.2022.105948. Epub 2022 Dec 5.
6
Mitochondria Transfer in Brain Injury and Disease.线粒体在脑损伤和疾病中的转移。
Cells. 2022 Nov 14;11(22):3603. doi: 10.3390/cells11223603.
7
Molecular basis of astrocyte diversity and morphology across the CNS in health and disease.中枢神经系统中星形胶质细胞多样性和形态的分子基础：在健康和疾病中的表现。
Science. 2022 Nov 4;378(6619):eadc9020. doi: 10.1126/science.adc9020.
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Ulinastatin alleviates early brain injury after intracerebral hemorrhage by inhibiting oxidative stress and neuroinflammation via ROS/MAPK/Nrf2 signaling pathway.乌司他丁通过抑制氧化应激和神经炎症反应，经 ROS/MAPK/Nrf2 信号通路减轻脑出血后早期脑损伤。
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