Gomes Inês, Jesus Emanuel, Sousa Gabriela M
Medical Oncology, Instituto Português de Oncologia de Coimbra Francisco Gentil, Coimbra, PRT.
Cureus. 2024 Jan 29;16(1):e53138. doi: 10.7759/cureus.53138. eCollection 2024 Jan.
Opsoclonus-ataxia paraneoplastic syndrome (OAPS) is a rare neurological disorder often associated with malignancies. This case report highlights an unusual instance of OAPS linked to a yolk sac (germ cell) tumor, a correlation underrepresented in the medical literature. The patient presented with distinct neurological symptoms alongside mediastinal lymphadenopathies. The subsequent diagnostic journey revealed a yolk sac germ cell tumor. Following incisional biopsies and treatment, the patient experienced fluctuations in mental status, leading to challenges in initiating chemotherapy. Despite these complications, a multidisciplinary approach involving neurologists, oncologists, and hematologists was pivotal. The case emphasizes the complexities of managing OAPS in tandem with a germ cell tumor, underscoring the need for further research and highlighting the significance of specialized neurological evaluation in similar cases.
眼阵挛-共济失调副肿瘤综合征（OAPS）是一种罕见的神经系统疾病，常与恶性肿瘤相关。本病例报告突出了一例与卵黄囊（生殖细胞）肿瘤相关的不寻常OAPS病例，这种关联在医学文献中较少提及。患者出现明显的神经系统症状以及纵隔淋巴结肿大。随后的诊断过程发现了卵黄囊生殖细胞肿瘤。在进行切开活检和治疗后，患者的精神状态出现波动，导致启动化疗面临挑战。尽管出现了这些并发症，但由神经科医生、肿瘤科医生和血液科医生组成的多学科方法至关重要。该病例强调了同时管理OAPS和生殖细胞肿瘤的复杂性，强调了进一步研究的必要性，并突出了在类似病例中进行专业神经学评估的重要性。
