Department of GI Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, Hubei, China.
GI Cancer Research Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, Hubei, China.
Front Biosci (Landmark Ed). 2024 Feb 21;29(2):72. doi: 10.31083/j.fbl2902072.
The mitochondrial antiviral-signaling protein (MAVS), a core adaptor protein in the retinoic-acid-inducible gene-I-like receptors (RLRs)-MAVS pathway, has been demonstrated to play an important role in antiviral immune response and tumor immunology. Previous studies revealed that ubiquitylation is a key mechanism in the regulation of the RLRs-MAVS axis and immune response. Multiple E3 ubiquitin ligases and deubiquitinating enzymes control MAVS ubiquitylation and changes in MAVS function. In this review, we summarize the biological function of ubiquitylation in MAVS-related signaling and provide new insight into immunotherapy approaches that target MAVS.
线粒体抗病毒信号蛋白（MAVS）是视黄酸诱导基因-I 样受体（RLRs）-MAVS 通路中的核心衔接蛋白，已被证明在抗病毒免疫反应和肿瘤免疫学中发挥重要作用。先前的研究表明，泛素化是调节 RLRs-MAVS 轴和免疫反应的关键机制。多种 E3 泛素连接酶和去泛素化酶控制 MAVS 的泛素化和 MAVS 功能的变化。在这篇综述中，我们总结了 MAVS 相关信号中泛素化的生物学功能，并为靶向 MAVS 的免疫治疗方法提供了新的见解。
