Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia; Students' University Hospital, Mansoura University, Mansoura, Egypt.
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Profiles Drug Subst Excip Relat Methodol. 2024;49:81-114. doi: 10.1016/bs.podrm.2023.11.005. Epub 2024 Jan 25.
Ponatinib is a prescription medication used to treat a rare form of blood cancer called Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) and chronic myeloid leukemia (CML) that is resistant to other treatments. It belongs to a class of drugs called tyrosine kinase inhibitors, which work by blocking abnormal proteins that promote the growth of cancer cells. In this chapter, the synthesis methods and physicochemical properties of ponatinib were reviewed, besides the characterization of the ponatinib structure using different techniques such as elemental analysis, IR, UV, (H and C) NMR, MS, and XRD. Furthermore, the compendial method for analysis of ponatinib was not found, while the literature review of a non-compendial method for analysis of ponatinib, such as spectroscopic, chromatographic, and immunoassay methods, was covered. Moreover, pharmacology and biochemistry were surveyed in the pharmacokinetic and pharmacodynamic studies.
泊那替尼是一种处方药物，用于治疗一种罕见的血癌，称为费城染色体阳性急性淋巴细胞白血病（Ph+ ALL）和慢性髓性白血病（CML），对其他治疗方法有抗药性。它属于一类称为酪氨酸激酶抑制剂的药物，通过阻断促进癌细胞生长的异常蛋白质起作用。在这一章中，综述了泊那替尼的合成方法和物理化学性质，并使用元素分析、IR、UV、（H 和 C）NMR、MS 和 XRD 等不同技术对泊那替尼结构进行了表征。此外，未发现泊那替尼的分析方法，而对泊那替尼的非药典分析方法，如光谱、色谱和免疫测定方法的文献综述进行了综述。此外，在药代动力学和药效学研究中调查了药理学和生物化学。
