Unidad de Insuficiencia Cardiaca Avanzada y Trasplante Cardiaco, Servicio de Cardiología. Complexo Hospitalario Universitario A Coruña (CHUAC), A Coruña, España; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, España.
Hospital Universitario Virgen de las Nieves, Granada, España.
Med Clin (Barc). 2024 Apr 12;162(7):e1-e7. doi: 10.1016/j.medcli.2024.01.005. Epub 2024 Feb 28.
Cardiac amyloidosis (CA) is a disorder associated with high number of hospital admissions. Given the scarce information available, we propose an analysis of the incidence and causes of hospitalization in this disease.
One hundred and forty-three patients [128 by transthyretin (ATTR-CA) and 15 by light chains (AL-CA)] included in Registro de Amiloidosis Cardiaca de Galicia (AMIGAL) were evaluated, including all hospitalizations.
During a median follow-up of 959 days there were 179 unscheduled hospitalizations [incidence rate (IR) 512.6 admissions per 1000 patients-year], most common due to cardiovascular reasons (n=109, IR 312.2). Most frequent individual cause of hospitalization was heart failure (n=87, TI 249.2). AL-CA was associated with a higher IR of unscheduled hospitalizations than ATTR-CA (IR 781 vs. 483.2; HR 1.62; p=0,029) due to non-cardiovascular admissions (IR 376 vs. 181.2; HR 2.07; p=0.027). Unscheduled admission-free survival at 1 and 3 years in AL-CA was inferior than in ATTR-CA (46.7% and 20.0% vs. 73.4% and 35.2%, respectively; p=0.021).
CA was associated with high incidence of hospitalizations, being heart failure the most frequent individual cause; unscheduled admission-free survival in AL-CA was lower than in ATTR-CA due mostly to non-cardiovascular admissions.
心脏淀粉样变（CA）是一种与多次住院相关的疾病。鉴于可用信息有限，我们提出分析该疾病的住院发病率和原因。
评估了 143 名患者[128 名由转甲状腺素（ATTR-CA）和 15 名由轻链（AL-CA）引起]，包括所有住院患者。
在中位数为 959 天的随访期间，发生了 179 次非计划住院[发病率（IR）为每 1000 名患者年 512.6 次住院]，最常见的原因是心血管原因（n=109，IR 312.2）。最常见的单个住院原因是心力衰竭（n=87，TI 249.2）。由于非心血管住院，AL-CA 的非计划住院 IR 高于 ATTR-CA（IR 781 比 483.2；HR 1.62；p=0.029），IR 376 比 181.2；HR 2.07；p=0.027）。AL-CA 患者在 1 年和 3 年的无计划住院生存分别低于 ATTR-CA（46.7%和 20.0%比 73.4%和 35.2%；p=0.021）。
CA 与高住院率相关，心力衰竭是最常见的单个病因；由于非心血管住院，AL-CA 的无计划住院生存率低于 ATTR-CA。
