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院前外周血管加压素的安全性:SPOTLESS 研究(院前外周血管加压素的安全性研究)。

Safety of pre-hospital peripheral vasopressors: The SPOTLESS study (Safety of PrehOspiTaL pEripheral vaSopreSsors).

机构信息

Lifeflight Retrieval Medicine, Brisbane, Queensland, Australia.

High Acuity Response Unit, Queensland Ambulance Service, Brisbane, Queensland, Australia.

出版信息

Emerg Med Australas. 2024 Aug;36(4):547-553. doi: 10.1111/1742-6723.14396. Epub 2024 Feb 29.

DOI:10.1111/1742-6723.14396
PMID:38423993
Abstract

OBJECTIVE

To assess the safety and effectiveness of peripheral vasoactive drugs initiated during pre-hospital care and retrieval missions, in Queensland, Australia.

METHODS

Three years of retrospective data was gathered from two sources. Medical notes were reviewed using a search for any patient having 'inotrope' recorded on an electronic medical record. Each case was reviewed to include only peripheral infusions of adrenaline or noradrenaline. Clinical Governance records were searched for adverse events related to vasoactive drugs, alerted for review to ensure complete capture.

RESULTS

A total of 418 patients received peripheral infusions of adrenaline and noradrenaline over the 3-year period. No major complications were recorded either immediately or at Clinical Governance review. Minor complications were recorded in 4.7% of the cases, of which 3.5% occurred with peripheral vasoactives during the presence of the retrieval team. The frequency of use of peripheral vasoactives increased over the study period.

CONCLUSIONS

In this retrospective data set there were no major complications of peripheral vasoactive drugs. Minor complications were similar to in-hospital use and related to vascular access and drug delivery.

摘要

目的

评估在澳大利亚昆士兰州的院前护理和救援任务中使用外周血管活性药物的安全性和有效性。

方法

从两个来源收集了三年的回顾性数据。使用电子病历中记录的“儿茶酚胺”对医疗记录进行了检索,以审查每个病例,仅包括肾上腺素或去甲肾上腺素的外周输注。检索临床治理记录,以寻找与血管活性药物相关的不良事件,并进行审查,以确保完全捕获。

结果

在 3 年期间,共有 418 名患者接受了肾上腺素和去甲肾上腺素的外周输注。无论是立即还是在临床治理审查中,都没有记录到重大并发症。在 4.7%的病例中记录到轻微并发症,其中 3.5%在救援团队在场时发生在外周血管活性药物治疗中。外周血管活性药物的使用频率在研究期间有所增加。

结论

在这个回顾性数据集中,外周血管活性药物没有出现重大并发症。轻微并发症与院内使用情况相似,与血管通路和药物输送有关。

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