Department of Cardiology, The Affiliated Hospital of Chengde Medical University, Chengde, China.
Hebei Key Laboratory of Panvascular Diseases, Chengde, China.
Clin Cardiol. 2024 Feb;47(3):e24246. doi: 10.1002/clc.24246.
Lipid metabolism related factors, such as angiopoietin-like protein 3 (ANGPTL3), angiopoietin-like 4 (ANGPTL4), fatty acid-binding protein 4 (FABP4) are newly discovered factors that can affect coronary artery disease (CAD). In this study, we aimed to investigate the relationship between CAD and these lipid metabolism factors.
ANGPTL3, ANGPTL4, and FABP4 may provide a new method for the control of CAD risk factors and the prevention and treatment of CAD.
We enrolled 284 consecutive inpatients with suspected CAD and divided them into CAD and non-CAD groups based on the coronary angiography results. Serum ANGPTL3, ANGPTL4, FABP4, and tumor necrosis factor-α (TNF-α) levels were estimated using the enzyme-linked immunosorbent assay. Multivariate logistic regression was used to assess the risk factors for CAD. The receiver operating characteristic curve was used to determine the cutoff and diagnostic values.
The serum TNF-α, FABP4, ANGPTL3, and ANGPTL4 values showed a significant difference between the CAD and non-CAD groups (p < .05). After adjusting for confounding factors, the FABP4, ANGPTL3, and ANGPTL4 levels were independently associated with CAD (p < .05). The ANGPTL3 expression level was an independent risk factor for CAD in patients with hypertension, but not in those without hypertension. The ANGPTL3 > 67.53 ng/mL, ANGPTL4 > 29.95 ng/mL, and FABP4 > 1421.25 ng/L combination had the highest diagnostic value for CAD.
ANGPTL3, ANGPTL4, and FABP4 were identified as independent risk factors for CAD and have valuable clinical implications for the diagnosis and treatment of CAD.
脂代谢相关因子，如血管生成素样蛋白 3（ANGPTL3）、血管生成素样蛋白 4（ANGPTL4）、脂肪酸结合蛋白 4（FABP4），是新发现的可影响冠状动脉疾病（CAD）的因子。本研究旨在探讨 CAD 与这些脂代谢因子的关系。
ANGPTL3、ANGPTL4 和 FABP4 可能为控制 CAD 危险因素和预防及治疗 CAD 提供新方法。
连续纳入 284 例疑似 CAD 的住院患者，根据冠状动脉造影结果分为 CAD 组和非 CAD 组。采用酶联免疫吸附试验测定血清 ANGPTL3、ANGPTL4、FABP4 和肿瘤坏死因子-α（TNF-α）水平。采用多变量 logistic 回归评估 CAD 的危险因素。采用受试者工作特征曲线确定截断值和诊断价值。
CAD 组和非 CAD 组的血清 TNF-α、FABP4、ANGPTL3 和 ANGPTL4 值差异有统计学意义（p<0.05）。校正混杂因素后，FABP4、ANGPTL3 和 ANGPTL4 水平与 CAD 独立相关（p<0.05）。ANGPTL3 表达水平是高血压患者 CAD 的独立危险因素，但在非高血压患者中不是。ANGPTL3>67.53ng/mL、ANGPTL4>29.95ng/mL 和 FABP4>1421.25ng/L 联合对 CAD 具有最高的诊断价值。
ANGPTL3、ANGPTL4 和 FABP4 是 CAD 的独立危险因素，对 CAD 的诊断和治疗具有重要的临床意义。
