Panyu Central Hospital, Guangzhou, Guangdong, China.
Front Public Health. 2024 Feb 15;12:1356459. doi: 10.3389/fpubh.2024.1356459. eCollection 2024.
Studies on the association between mixed exposure to common pollutants such as cadmium (Cd), cobalt (Co), lead (Pb), and polycyclic aromatic hydrocarbons (PAHs) with Systemic Immune Inflammatory Index (SII), a novel hemocyte-based inflammatory marker, have not been reported. This study explored the relationship between co-exposure to Cd, Co, Pb, PAHs, and SII.
In this study, we used data from the National Health and Nutrition Examination Survey and enrolled adults with complete information on Cd, Co, Pb, PAHs, and SII. The linear regression was used to analyze the association of single pollutants with SII. Furthermore, a Bayesian Kernel Machine Regression analysis and a generalized weighted quantile sum regression analysis were used to analyze the association between mixed exposure to Cd, Co, Pb, and six PAHs and SII. We also separated males and females and analyzed the different effects of pollutants on SII, respectively.
5,176 participants were included in the study. After adjusting for age, gender, race, education, smoking, drinking, physical activity, and sedentary, Cd, Co, 1-OHN, 2-OHN and 2-OHF were positive with SII in the total population. Compared with the 50th percentile, the joint effect of pollutants on SII was positive. In the total population, males, and females, the top contaminant with the highest effect weights on SII were Co, Cd, and 1-OHN, respectively. The result of interaction analysis showed that the low concentrations of Cd had an elevation effect on SII in males.
This study found a positive association of mixed exposure to Cd, Co, Pb, and six PAHs with SII, which occurred mainly in females.
目前尚未有研究报道混合暴露于常见污染物（如镉（Cd）、钴（Co）、铅（Pb）和多环芳烃（PAHs））与新型血细胞炎症标志物系统性免疫炎症指数（SII）之间的关系。本研究旨在探讨共同暴露于 Cd、Co、Pb 和六种 PAHs 与 SII 的关系。
本研究使用了来自全国健康与营养调查的数据，纳入了具有完整 Cd、Co、Pb、PAHs 和 SII 信息的成年人。采用线性回归分析单污染物与 SII 的关系。此外，采用贝叶斯核机器回归分析和广义加性权重求和回归分析来分析 Cd、Co、Pb 混合暴露与 SII 之间的关系，以及 6 种 PAHs 与 SII 之间的关系。我们还分别对男性和女性进行了分离，并分析了污染物对 SII 的不同影响。
本研究共纳入 5176 名参与者。在校正了年龄、性别、种族、教育程度、吸烟、饮酒、体力活动和久坐行为等因素后，发现全人群中 Cd、Co、1-OHN、2-OHN 和 2-OHF 与 SII 呈正相关。与第 50 百分位数相比，污染物对 SII 的联合效应呈正相关。在全人群、男性和女性中，对 SII 影响最大的污染物分别为 Co、Cd 和 1-OHN。交互分析结果表明，低浓度 Cd 在男性中对 SII 有升高作用。
本研究发现混合暴露于 Cd、Co、Pb 和六种 PAHs 与 SII 呈正相关，这种相关性主要发生在女性中。
