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烧伤后颈面部坏死性筋膜炎合并糖尿病酮症酸中毒:一例预后良好的病例报告

Post-burn Cervicofacial Necrotizing Fasciitis With Diabetic Ketoacidosis: A Report of a Case With a Favorable Outcome.

作者信息

Kakkad Jasleen, Jain Shraddha, Reddy Venkat, Saboo Keyur, Naseri Suhit

机构信息

Otolaryngology - Head and Neck Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

General Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

出版信息

Cureus. 2024 Jan 30;16(1):e53219. doi: 10.7759/cureus.53219. eCollection 2024 Jan.

DOI:10.7759/cureus.53219
PMID:38425638
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10902738/
Abstract

Post-burn necrotizing fasciitis (PBNF) is a serious and potentially life-threatening infection that occurs after a burn injury. It is characterized by rapid destruction of soft tissue and muscle and is usually caused by a bacterial infection. Diabetic ketoacidosis (DKA) is another serious complication of diabetes, which can occur when the body does not have enough insulin to break down glucose for energy. This causes the body to start breaking down fat for energy instead, leading to various complications. The present study discusses the association between PBNF and DKA in a patient with diabetes. Here is a case of a post-auricular abscess and a precipitated DKA. The abscess was located near the site of the previous burn injury that happened 20 years ago and was believed to have developed as a result of thick scar tissue. The patient was given adequate hydration, intravenous antibiotics, and insulin therapy. However, the abscess continued to grow with increasing insulin requirements and the patient underwent incision and drainage to remove the infected tissue, and an aggressive debridement was carried out. Thus, this case highlights the importance of closely monitoring blood sugar levels in patients with a history of burn injury and diabetes, as well as the potential for infections to precipitate DKA. Timely intervention, including incision and drainage, can lead to successful resolution of symptoms and improved outcomes.

摘要

烧伤后坏死性筋膜炎(PBNF)是一种烧伤后发生的严重且可能危及生命的感染。其特征是软组织和肌肉迅速破坏,通常由细菌感染引起。糖尿病酮症酸中毒(DKA)是糖尿病的另一种严重并发症,当身体没有足够的胰岛素来分解葡萄糖以供能时就会发生。这会导致身体转而分解脂肪以供能,从而引发各种并发症。本研究探讨了一名糖尿病患者中PBNF与DKA之间的关联。这里有一个耳后脓肿并诱发DKA的病例。脓肿位于20年前发生的既往烧伤部位附近,据信是由于厚厚的瘢痕组织而形成的。患者接受了充分的补液、静脉抗生素治疗和胰岛素治疗。然而,随着胰岛素需求量增加,脓肿持续增大,患者接受了切开引流以清除感染组织,并进行了积极的清创。因此,该病例凸显了密切监测有烧伤和糖尿病病史患者血糖水平的重要性,以及感染诱发DKA的可能性。及时干预,包括切开引流,可导致症状成功缓解并改善预后。

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本文引用的文献

1
Cervical Necrotizing Fasciitis, Diagnosis and Treatment of a Rare Life-Threatening Infection.颈部坏死性筋膜炎:一种罕见的危及生命感染的诊断与治疗
Ear Nose Throat J. 2023 Mar;102(3):NP109-NP113. doi: 10.1177/0145561321991341. Epub 2021 Feb 11.
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The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System.2 型糖尿病对器官代谢和免疫系统的影响。
Front Immunol. 2020 Jul 22;11:1582. doi: 10.3389/fimmu.2020.01582. eCollection 2020.
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Management of necrotising fasciitis within a burns centre: do outcomes differ?
烧伤中心内坏死性筋膜炎的管理:结果有差异吗?
Scars Burn Heal. 2020 Jun 30;6:2059513120924749. doi: 10.1177/2059513120924749. eCollection 2020 Jan-Dec.
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Diabetic ketoacidosis.糖尿病酮症酸中毒。
Nat Rev Dis Primers. 2020 May 14;6(1):40. doi: 10.1038/s41572-020-0165-1.
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Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.禁食代谢对细菌和病毒感染性炎症中组织耐受性的相反作用。
Cell. 2016 Sep 8;166(6):1512-1525.e12. doi: 10.1016/j.cell.2016.07.026.
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Necrotizing fasciitis in patients with diabetes mellitus: clinical characteristics and risk factors for mortality.糖尿病患者的坏死性筋膜炎:临床特征及死亡风险因素
BMC Infect Dis. 2015 Oct 13;15:417. doi: 10.1186/s12879-015-1144-0.
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SGLT2 Inhibitors May Predispose to Ketoacidosis.钠-葡萄糖协同转运蛋白2(SGLT2)抑制剂可能易引发酮症酸中毒。
J Clin Endocrinol Metab. 2015 Aug;100(8):2849-52. doi: 10.1210/jc.2015-1884. Epub 2015 Jun 18.
8
Facial necrotizing fasciitis disclosing systemic lupus erythematosus.面部坏死性筋膜炎揭示系统性红斑狼疮。
Indian J Dermatol. 2013 Mar;58(2):163. doi: 10.4103/0019-5154.108105.
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Necrotizing fasciitis: is the bacterial spectrum changing?坏死性筋膜炎:细菌谱在变化吗?
Langenbecks Arch Surg. 2013 Jan;398(1):153-9. doi: 10.1007/s00423-012-0983-z. Epub 2012 Jul 26.
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Necrotizing fasciitis of the face: a life-threatening condition.面部坏死性筋膜炎:一种危及生命的疾病。
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