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创伤性脑损伤啮齿动物模型中的睡眠、炎症与血流动力学

Sleep, inflammation, and hemodynamics in rodent models of traumatic brain injury.

作者信息

Green Tabitha R F, Carey Sean D, Mannino Grant, Craig John A, Rowe Rachel K, Zielinski Mark R

机构信息

Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States.

Veterans Affairs (VA) Boston Healthcare System, West Roxbury, MA, United States.

出版信息

Front Neurosci. 2024 Feb 15;18:1361014. doi: 10.3389/fnins.2024.1361014. eCollection 2024.

DOI:10.3389/fnins.2024.1361014
PMID:38426017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10903352/
Abstract

Traumatic brain injury (TBI) can induce dysregulation of sleep. Sleep disturbances include hypersomnia and hyposomnia, sleep fragmentation, difficulty falling asleep, and altered electroencephalograms. TBI results in inflammation and altered hemodynamics, such as changes in blood brain barrier permeability and cerebral blood flow. Both inflammation and altered hemodynamics, which are known sleep regulators, contribute to sleep impairments post-TBI. TBIs are heterogenous in cause and biomechanics, which leads to different molecular and symptomatic outcomes. Animal models of TBI have been developed to model the heterogeneity of TBIs observed in the clinic. This review discusses the intricate relationship between sleep, inflammation, and hemodynamics in pre-clinical rodent models of TBI.

摘要

创伤性脑损伤（TBI）可导致睡眠失调。睡眠障碍包括嗜睡和失眠、睡眠片段化、入睡困难以及脑电图改变。TBI会引发炎症和血流动力学改变，如血脑屏障通透性和脑血流量的变化。炎症和血流动力学改变均为已知的睡眠调节因子，它们共同导致了TBI后的睡眠障碍。TBI在病因和生物力学方面具有异质性，这导致了不同的分子和症状结果。已经建立了TBI动物模型来模拟临床上观察到的TBI的异质性。本综述讨论了TBI临床前啮齿动物模型中睡眠、炎症和血流动力学之间的复杂关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c184/10903352/b89b3756bca9/fnins-18-1361014-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c184/10903352/6879e95b953c/fnins-18-1361014-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c184/10903352/b89b3756bca9/fnins-18-1361014-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c184/10903352/6879e95b953c/fnins-18-1361014-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c184/10903352/b89b3756bca9/fnins-18-1361014-g002.jpg

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