Raniga Dipesh, Goda Mina, Hattingh Laetitia, Thorning Sarah, Rowe Matthew, Howes Laurie
Department of Cardiology, Division of Specialist Medical Services, Gold Coast Hospital and Health Services, Southport, QLD 4215, Australia.
Allied Health Research, Gold Coast Hospital and Health Services, Southport, QLD 4215, Australia.
Int J Cardiol Heart Vasc. 2024 Feb 23;51:101364. doi: 10.1016/j.ijcha.2024.101364. eCollection 2024 Apr.
This systematic review and -analysis was conducted to determine the clinical relevance of echocardiographically measured left atrial (LA) size to predict the recurrence of atrial fibrillation (AF) after direct current cardioversion (DCCV). A search was performed on Medline (Ovid), Embase (Elsevier), Cochrane Central Register of Controlled Trials (CENTRAL) in Cochrane Library, Wiley and Web of Science (Clarivate) to identify relevant studies. Amongst the initial 4066 citations identified, 31 fulfilled the criteria for inclusion in the data analysis incorporating 2725 patients with a mean follow-up period of 6.5 months. The weighted mean left atrial volume index (LAVI) was 40.56 ml/m (95 %CI:37.24-43.88) in the sinus rhythm (SR) maintenance group versus 48.69 ml/m (95 % CI: 44.42-52.97) in the AF recurrence group with P value of < 0.001, left atrial diameter (LAD) was 42.06 mm (95 %CI: 41.08-43.05) in the SR maintenance group versus 45.13 mm (95 %CI: 44.09-46.16) in the AF recurrence group, P value < 0.001. Effect size analysis of LAVI showed that each unit increase in LAVI resulted in an increase in the risk of AF recurrence by 6 % (95 % CI: 3 %-10 %). Age and AF duration were also statistically significant between the two groups however comorbidities, use of beta blockers or amiodarone were not significantly different. This -analysis shows that AF duration, LAVI, LAD and age predict the risk of recurrence of atrial fibrillation post electrical cardioversion with LAVI being the most clinically relevant echocardiographic feature.
进行这项系统评价和分析的目的是确定经超声心动图测量的左心房(LA)大小对预测直流电复律(DCCV)后房颤(AF)复发的临床相关性。我们在Medline(Ovid)、Embase(Elsevier)、Cochrane图书馆的Cochrane对照试验中心注册库(CENTRAL)、Wiley和Web of Science(Clarivate)上进行了检索,以识别相关研究。在最初识别出的4066篇文献中,31篇符合纳入数据分析的标准,纳入了2725例患者,平均随访期为6.5个月。窦性心律(SR)维持组的加权平均左心房容积指数(LAVI)为40.56ml/m²(95%CI:37.24 - 43.88),而房颤复发组为48.69ml/m²(95%CI:44.42 - 52.97),P值<0.001;SR维持组的左心房直径(LAD)为42.06mm(95%CI:41.08 - 43.05),房颤复发组为45.13mm(95%CI:44.09 - 46.16),P值<0.001。LAVI的效应量分析表明,LAVI每增加一个单位,房颤复发风险增加6%(95%CI:3% - 10%)。两组之间年龄和房颤持续时间也具有统计学意义,但合并症、β受体阻滞剂或胺碘酮的使用无显著差异。该分析表明,房颤持续时间、LAVI、LAD和年龄可预测电复律后房颤复发的风险,其中LAVI是最具临床相关性的超声心动图特征。