Grupo de Bioestadística Aplicada, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and CONICET, Buenos Aires, Argentina.
Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos, CONICET, Hospital "El Cruce", Universidad Arturo Jauretche, Florencio Varela, Argentina.
Am J Biol Anthropol. 2024 Jun;184(2):e24921. doi: 10.1002/ajpa.24921. Epub 2024 Mar 1.
To investigate the association between the anthropometric status at birth and brain and bone growth during the first year of life. According to the brain-sparing hypothesis, we expect catch-up to be faster in head circumference (HC) than in body length.
This is a longitudinal design that included Argentinian infants under 12 months of age with at least three anthropometric records. We classified study participants into four growth status categories according to z-scores for HC (HCZ) and length (LAZ) at birth, with z-score = -2 as a threshold. We used the Count model to describe growth trajectories in HC and length in the first year of life according to the growth status at birth. Recovery indicator for HC and length was taken as the time until the predicted growth trajectory surpassed the threshold curve predicted by z-score = -2 for age.
Growth models included 3399 infants. There were significant differences in the growth parameters between groups in all cases (p < 0.05). Within the group with a low HCZ and a low LAZ at birth, HC recovery was faster than length. In the case of a low z-score for only one of the variables, newborns with a low HCZ recovered faster than individuals born with a low LAZ.
The postnatal growth pattern in HC and length is associated with the growth status of HC and length at birth. As we hypothesized, the fastest postnatal recovery occurs for HC in cases of intrauterine delayed growth.
研究出生时的人体测量学状况与生命第一年大脑和骨骼生长之间的关系。根据大脑节约假说，我们预计头围（HC）的追赶生长速度会快于身长。
这是一项纵向设计，纳入了至少有 3 次人体测量记录的 12 个月以下的阿根廷婴儿。我们根据出生时 HC（HCZ）和长度（LAZ）的 z 分数将研究参与者分为四个生长状态类别，以 z 分数=-2 作为阈值。我们使用计数模型根据出生时的生长状态描述 HC 和长度在生命第一年的生长轨迹。HC 和长度的恢复指标为预测生长轨迹超过 z 分数=-2 预测的年龄曲线的时间。
生长模型包括 3399 名婴儿。在所有情况下，各组的生长参数均存在显著差异（p<0.05）。在出生时 HCZ 和 LAZ 均较低的组中，HC 的恢复速度快于长度。在仅一个变量 z 分数较低的情况下，HCZ 较低的新生儿比 LAZ 较低的新生儿恢复更快。
HC 和长度的产后生长模式与出生时 HC 和长度的生长状态有关。正如我们假设的那样，在宫内生长迟缓的情况下，HC 出现最快的产后恢复。
