Department of Translational Medicine, Università del Piemonte Orientale, Novara.
Department of Health Sciences, Università del Piemonte Orientale, Novara.
Haematologica. 2024 Jul 1;109(7):2041-2048. doi: 10.3324/haematol.2022.282272.
Hemostasis is a sophisticated sequence of events aimed at repairing vessel injury. This process occurs in combination with angiogenesis, which leads to new blood vessel formation, helping in wound repair and facilitating tissue healing. The fine mechanisms that regulate hemostasis and angiogenesis are well described, but for a long time, coagulation factors (CF) have been considered merely players in the coagulation cascade. However, evidence from several experiments highlights the crucial functions of these CF in regulating endothelial functionality, especially in the angiogenic process. Some of these CF (e.g., thrombin and tissue factor) have been widely investigated and have been described as triggering intracellular signaling related to endothelial cell (EC) functionality. For others (e.g., factor VIII and thrombomodulin), potential receptors and molecular mechanisms have not been fully elucidated but some data show their potential to induce EC response. This review focuses on the emerging roles of selected CF in regulating EC functions, highlighting in particular their ability to activate signaling pathways involved in angiogenesis, migration, proliferation and endothelial barrier stability.
止血是一个复杂的事件序列，旨在修复血管损伤。这个过程与血管生成相结合，导致新的血管形成，有助于伤口修复和促进组织愈合。调节止血和血管生成的精细机制已经得到很好的描述，但很长一段时间以来，凝血因子（CF）仅被认为是凝血级联反应中的参与者。然而，来自几项实验的证据强调了这些 CF 在调节内皮功能方面的关键作用，特别是在血管生成过程中。其中一些 CF（例如凝血酶和组织因子）已经得到了广泛的研究，并被描述为触发与内皮细胞（EC）功能相关的细胞内信号。对于其他一些 CF（例如因子 VIII 和血栓调节蛋白），潜在的受体和分子机制尚未完全阐明，但一些数据表明它们有诱导 EC 反应的潜力。这篇综述重点介绍了选定的 CF 在调节 EC 功能方面的新作用，特别强调了它们激活参与血管生成、迁移、增殖和内皮屏障稳定性的信号通路的能力。
