Herrmann J, Elejalde B R
Natl Cancer Inst Monogr. 1979 May(51):7-18.
Clinical and genetic aspects of pediatric neoplasms were reviewed from pathogenetic and etiologic perspectives. Developmental principles and phenomena common to several tumors and tumor syndromes were identified, summarized, and critically evaluated. Their enumeration may be useful in future cancer research. No single hypothesis on the cause and pathogenesis of cancer appears to apply to all disorders. We believe that multiple causes and pathways lead to the phenotype "cancer" and that in particular the pathogenetic relationship between tissue dysplasias and cancers deserves increased attention.
从发病机制和病因学角度对儿童肿瘤的临床和遗传学方面进行了综述。确定、总结并批判性评估了几种肿瘤和肿瘤综合征共有的发育原理和现象。对它们的列举可能对未来的癌症研究有用。关于癌症病因和发病机制的单一假设似乎并不适用于所有疾病。我们认为，多种原因和途径导致了“癌症”这一表型，特别是组织发育异常与癌症之间的发病机制关系值得更多关注。
