• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基线促肾上腺皮质激素释放激素依赖性和快速眼动睡眠剥夺。

Baseline prepulse inhibition dependency of orexin A and REM sleep deprivation.

机构信息

Department of Molecular Biology and Genetics, Üsküdar University, Istanbul, Turkey.

Faculty of Engineering and Natural Sciences, Üsküdar University Central Campus Block A, Altunizade Mah. Haluk Türksoy Sk. No : 14 34362, Üsküdar, Istanbul, Turkey.

出版信息

Psychopharmacology (Berl). 2024 Jun;241(6):1213-1225. doi: 10.1007/s00213-024-06555-3. Epub 2024 Mar 1.

DOI:10.1007/s00213-024-06555-3
PMID:38427059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11106105/
Abstract

RATIONALE

Prepulse inhibition (PPI) impairment reflects sensorimotor gating problems, i.e. in schizophrenia. This study aims to enlighten the role of orexinergic regulation on PPI in a psychosis-like model.

OBJECTIVES

In order to understand the impact of orexinergic innervation on PPI and how it is modulated by age and baseline PPI (bPPI), chronic orexin A (OXA) injections was carried on non-sleep-deprived and sleep-deprived rats that are grouped by their bPPI.

METHODS

bPPI measurements were carried on male Wistar rats on P45 or P90 followed by grouping into low-PPI and high-PPI rats. The rats were injected with OXA twice per day for four consecutive days starting on P49 or P94, while the control groups received saline injections. 72 h REMSD was carried on via modified multiple platform technique on P94 and either OXA or saline was injected during REMSD. PPI tests were carried out 30 min. after the last injection.

RESULTS

Our previous study with acute OXA injection after REMSD without bPPI grouping revealed that low OXA doses might improve REMSD-induced PPI impairment. Our current results present three important conclusions: (1) The effect of OXA on PPI is bPPI-dependent and age-dependent. (2) The effect of REMSD is bPPI-dependent. (3) The effect of OXA on PPI after REMSD also depends on bPPI.

CONCLUSION

Orexinergic regulation of PPI response with and without REMSD can be predicted by bPPI levels. Our findings provide potential insights into the regulation of sensorimotor gating by sleep/wakefulness systems and present potential therapeutic targets for the disorders, where PPI is disturbed.

摘要

原理

前脉冲抑制 (PPI) 损伤反映了感觉运动门控问题，即精神分裂症。本研究旨在阐明食欲素能调节对类精神病模型中 PPI 的作用。

目的

为了了解食欲素能神经支配对 PPI 的影响，以及它如何被年龄和基础 PPI（bPPI）调节，我们对非睡眠剥夺和睡眠剥夺的大鼠进行了慢性食欲素 A (OXA) 注射，这些大鼠根据其 bPPI 进行分组。

方法

在 P45 或 P90 对雄性 Wistar 大鼠进行 bPPI 测量，然后根据 bPPI 将大鼠分为低 PPI 和高 PPI 大鼠。从 P49 或 P94 开始，每天两次给大鼠注射 OXA，连续四天，而对照组接受盐水注射。在 P94 上通过改良的多个平台技术进行 72 h REMSD，并在 REMSD 期间注射 OXA 或盐水。在最后一次注射后 30 分钟进行 PPI 测试。

结果

我们之前的研究表明，在 REMSD 后急性注射 OXA 而不进行 bPPI 分组时，低剂量 OXA 可能会改善 REMSD 诱导的 PPI 损伤。我们目前的研究结果提出了三个重要结论：(1) OXA 对 PPI 的影响取决于 bPPI 水平和年龄。(2) REMSD 的作用取决于 bPPI。(3) REMSD 后 OXA 对 PPI 的影响也取决于 bPPI。

结论

有或没有 REMSD 的 OXA 对 PPI 反应的调节可以通过 bPPI 水平来预测。我们的发现为睡眠/觉醒系统对感觉运动门控的调节提供了潜在的见解，并为 PPI 受到干扰的疾病提供了潜在的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/11106105/62fdbfbd11a7/213_2024_6555_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/11106105/db719263ab04/213_2024_6555_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/11106105/4b894a13641c/213_2024_6555_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/11106105/24c538508622/213_2024_6555_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/11106105/4f4b83428dfe/213_2024_6555_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/11106105/cbc6bad12e5a/213_2024_6555_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/11106105/62fdbfbd11a7/213_2024_6555_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/11106105/db719263ab04/213_2024_6555_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/11106105/4b894a13641c/213_2024_6555_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/11106105/24c538508622/213_2024_6555_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/11106105/4f4b83428dfe/213_2024_6555_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/11106105/cbc6bad12e5a/213_2024_6555_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef1/11106105/62fdbfbd11a7/213_2024_6555_Fig6_HTML.jpg

相似文献

1
Baseline prepulse inhibition dependency of orexin A and REM sleep deprivation.基线促肾上腺皮质激素释放激素依赖性和快速眼动睡眠剥夺。
Psychopharmacology (Berl). 2024 Jun;241(6):1213-1225. doi: 10.1007/s00213-024-06555-3. Epub 2024 Mar 1.
2
Dose-dependent and opposite effects of orexin A on prepulse inhibition response in sleep-deprived and non-sleep-deprived rats.食欲素A对睡眠剥夺和未睡眠剥夺大鼠前脉冲抑制反应的剂量依赖性及相反作用。
Behav Brain Res. 2018 Jul 2;346:73-79. doi: 10.1016/j.bbr.2017.12.002. Epub 2017 Dec 10.
3
Effect of gabapentin on sleep-deprivation-induced disruption of prepulse inhibition.加巴喷丁对睡眠剥夺引起的条件性回避反射（PPI）破坏的影响。
Psychopharmacology (Berl). 2020 Oct;237(10):2993-3006. doi: 10.1007/s00213-020-05587-9. Epub 2020 Jun 27.
4
Effects of REM sleep deprivation on sensorimotor gating and startle habituation in rats: role of social isolation in early development.快速眼动睡眠剥夺对大鼠感觉运动门控和惊吓习惯化的影响：早期发育中社会隔离的作用。
Neurosci Lett. 2014 Jul 11;575:63-7. doi: 10.1016/j.neulet.2014.05.032. Epub 2014 May 23.
5
Tail-pinch stress and REM sleep deprivation differentially affect sensorimotor gating function in modafinil-treated rats.尾部夹捏应激和 REM 睡眠剥夺对莫达非尼治疗大鼠的感觉运动门控功能有不同影响。
Behav Brain Res. 2011 May 16;219(1):98-104. doi: 10.1016/j.bbr.2010.12.012. Epub 2010 Dec 15.
6
Prazosin modulates rapid eye movement sleep deprivation-induced changes in body temperature in rats.哌唑嗪可调节快速眼动睡眠剥夺诱导的大鼠体温变化。
J Sleep Res. 2009 Sep;18(3):349-56. doi: 10.1111/j.1365-2869.2008.00731.x. Epub 2009 Jun 22.
7
Neonatal quinpirole treatment produces prepulse inhibition deficits in adult male and female rats.新生期使用喹吡罗治疗会导致成年雄性和雌性大鼠出现前脉冲抑制缺陷。
Pharmacol Biochem Behav. 2015 Oct;137:93-100. doi: 10.1016/j.pbb.2015.08.011. Epub 2015 Aug 19.
8
Repeated REM sleep deprivation after chronic haloperidol administration in the rat.大鼠长期服用氟哌啶醇后反复进行快速眼动睡眠剥夺。
Psychopharmacology (Berl). 1997 Jun;131(3):216-9. doi: 10.1007/s002130050286.
9
Differential effect of clomipramine on habituation and prepulse inhibition in dominant versus subordinate rats.氯米帕明对优势大鼠和从属大鼠习惯化及前脉冲抑制的不同作用。
Eur Neuropsychopharmacol. 2016 Mar;26(3):591-601. doi: 10.1016/j.euroneuro.2015.12.025. Epub 2015 Dec 17.
10
Effects of rapid eye movement sleep deprivation on hypocretin neurons in the hypothalamus of a rat model of depression.快速眼动睡眠剥夺对抑郁症大鼠模型下丘脑促食欲素神经元的影响。
Neuropeptides. 2007 Oct;41(5):329-37. doi: 10.1016/j.npep.2007.04.006. Epub 2007 Jun 27.

本文引用的文献

1
Orexin deficiency affects sensorimotor gating and its amphetamine-induced impairment.食欲素缺乏会影响感觉运动门控及其由苯丙胺诱导的损伤。
Prog Neuropsychopharmacol Biol Psychiatry. 2022 Jun 8;116:110517. doi: 10.1016/j.pnpbp.2022.110517. Epub 2022 Jan 29.
2
Cognitive behavioral markers of neurodevelopmental trajectories in rodents.啮齿动物神经发育轨迹的认知行为标志物。
Transl Psychiatry. 2021 Oct 30;11(1):556. doi: 10.1038/s41398-021-01662-7.
3
Changes of Hypocretin (Orexin) System in Schizophrenia: From Plasma to Brain.
精神分裂症中食欲素（Hypocretin/Orexin）系统的变化：从血浆到大脑。
Schizophr Bull. 2021 Aug 21;47(5):1310-1319. doi: 10.1093/schbul/sbab042.
4
Effect of gabapentin on sleep-deprivation-induced disruption of prepulse inhibition.加巴喷丁对睡眠剥夺引起的条件性回避反射（PPI）破坏的影响。
Psychopharmacology (Berl). 2020 Oct;237(10):2993-3006. doi: 10.1007/s00213-020-05587-9. Epub 2020 Jun 27.
5
Controlled sleep deprivation as an experimental medicine model of schizophrenia: An update.受控睡眠剥夺作为精神分裂症的实验医学模型：更新。
Schizophr Res. 2020 Jul;221:4-11. doi: 10.1016/j.schres.2020.03.064. Epub 2020 May 8.
6
A higher body mass index in Chinese inpatients with chronic schizophrenia is associated with elevated plasma orexin-A levels and fewer negative symptoms.中国慢性精神分裂症住院患者较高的体重指数与血浆食欲素-A水平升高及较少的阴性症状相关。
Nord J Psychiatry. 2020 Oct;74(7):525-532. doi: 10.1080/08039488.2020.1755995. Epub 2020 May 4.
7
Effectiveness of Sleep Deprivation in Treating Acute Bipolar Depression as Augmentation Strategy: A Systematic Review and Meta-Analysis.睡眠剥夺作为增效策略治疗急性双相抑郁的有效性：一项系统评价和荟萃分析。
Front Psychiatry. 2020 Feb 25;11:70. doi: 10.3389/fpsyt.2020.00070. eCollection 2020.
8
Prepulse inhibition of the acoustic startle reflex and P50 gating in aging and alzheimer's disease.衰老和阿尔茨海默病中的听觉惊跳反射前脉冲抑制和 P50 门控。
Ageing Res Rev. 2020 May;59:101028. doi: 10.1016/j.arr.2020.101028. Epub 2020 Feb 21.
9
Reduced plasma orexin-A levels in patients with bipolar disorder.双相情感障碍患者血浆中食欲素-A水平降低。
Neuropsychiatr Dis Treat. 2019 Aug 6;15:2221-2230. doi: 10.2147/NDT.S209023. eCollection 2019.
10
Plasma neuropeptides as circulating biomarkers of multifactorial schizophrenia.血浆神经肽作为多因素精神分裂症的循环生物标志物。
Compr Psychiatry. 2019 Oct;94:152114. doi: 10.1016/j.comppsych.2019.152114. Epub 2019 Aug 5.