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克服对发展中国家的恐惧:一例T3A期肾细胞癌后腹腔镜下肾部分切除术的病例报告。

Overcoming fear of developing country: A case report of retroperitoneal laparoscopic partial nephrectomy for T3A renal cell carcinoma.

作者信息

Trang Vo Anh Vinh, Truyen Thien Tan Tri Tai, Nguyen Nam Hoang, Quach Giang Trieu, Pham Phu Phat, Nguyen Phuc Cam Hoang

机构信息

Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam.

Faculty of Medicine, Nam Can Tho University, Can Tho, Viet Nam.

出版信息

Int J Surg Case Rep. 2024 Mar;116:109450. doi: 10.1016/j.ijscr.2024.109450. Epub 2024 Feb 28.

Abstract

INTRODUCTION

Renal cell carcinoma poses significant challenges in kidney diseases, particularly in the context of the T3 stage, where treatment strategies remain controversial. The utilization of laparoscopic partial nephrectomy, particularly in developing countries, has been restricted for such patients, primarily due to limited infrastructure and concerns about recurrence risk and long-term pathologic outcomes.

PRESENTATION OF CASE

In this report, we present a case of a 64-year-old male diagnosed with T3aN0M0 renal cell carcinoma (RCC). Abdominal computed tomography revealed a 5.2 × 5.2 × 5.1 cm mass on the right upper part of the kidney with a possible thrombus in the superior renal polar vein. The patient underwent successful treatment with retroperitoneal laparoscopic partial nephrectomy (LPN), leading to the preservation of kidney function with <4 mL/min/1.73 m2 GFR reduced after one year postoperative (estimated GFR from 85 mL/min/1.73 m2 to 81.79 mL/min/1.73 m2). The patient was discharged after three days; no recurrence was observed during the follow-up.

DISCUSSION

For stage T3a RCC, studies show that LPN induces comparable long-term outcomes to radical nephrectomy, with advantages such as preserved kidney function, reduced operative time, blood loss, and shorter hospital stays. However, due to infrastructure constraints and limited access to robotic-assisted surgery in our country, coupled with concerns about tumor recurrence, laparoscopic radical nephrectomy is predominantly employed for similar patients. Our case represents one of the very first cases in which we successfully treated a patient diagnosed with T3a RCC using retroperitoneal laparoscopic partial nephrectomy.

CONCLUSION

Laparoscopic partial nephrectomy is a reliable choice for T3aN0M0 RCC with good long-term outcomes and preserved renal function, especially by the hands of an experienced laparoscopic surgeon.

摘要

引言

肾细胞癌在肾脏疾病中构成重大挑战,尤其是在T3期的情况下,治疗策略仍存在争议。腹腔镜部分肾切除术的应用,特别是在发展中国家,对于此类患者受到限制,主要是由于基础设施有限以及对复发风险和长期病理结果的担忧。

病例介绍

在本报告中,我们呈现了一例64岁男性被诊断为T3aN0M0肾细胞癌(RCC)的病例。腹部计算机断层扫描显示右肾上部有一个5.2×5.2×5.1厘米的肿块,肾上级静脉可能有血栓。患者接受了腹膜后腹腔镜部分肾切除术(LPN)并成功治疗,术后一年肾小球滤过率(GFR)降低至<4 mL/min/1.73 m²,肾功能得以保留(估计GFR从85 mL/min/1.73 m²降至81.79 mL/min/1.73 m²)。患者术后三天出院;随访期间未观察到复发。

讨论

对于T3a期肾细胞癌,研究表明腹腔镜部分肾切除术可诱导与根治性肾切除术相当的长期结果,具有保留肾功能、缩短手术时间、减少失血和缩短住院时间等优点。然而,由于我国基础设施限制以及机器人辅助手术的可及性有限,再加上对肿瘤复发的担忧,腹腔镜根治性肾切除术主要用于类似患者。我们的病例是我国首例成功使用腹膜后腹腔镜部分肾切除术治疗诊断为T3a期肾细胞癌患者的病例之一。

结论

腹腔镜部分肾切除术是T3aN0M0肾细胞癌的可靠选择,具有良好的长期结果和保留的肾功能,特别是在经验丰富的腹腔镜外科医生手中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28db/10944092/0b6cb10212f4/gr1.jpg

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