Department of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Medicine (Baltimore). 2024 Mar 1;103(9):e37394. doi: 10.1097/MD.0000000000037394.
Therapeutic resistance in cancer remains a dilemma that scientists and oncologists are eager to solve. Despite several preclinical and clinical studies dedicated to overcoming therapeutic resistance, they often do not yield the expected outcomes. This is primarily due to the multifactorial phenomenon of therapeutic resistance. Norcantharidin (NCTD) is an artificial compound derived from cantharidin that has significant anticancer efficacy without incurring serious side effects. Intriguingly, extensive research suggests that NCTD is essential for boosting anticancer efficacy and reversing treatment resistance. This review article presents a full description of how NCTD can effectively overcome cancer resistance to standard treatments such as chemotherapy, radiation, hormone therapy, and targeted therapy. We also discuss the potential prospects and challenges associated with using NCTD as a therapeutic strategy for reversing resistance to cancer therapy. We anticipate that our review will serve as a valuable reference for researchers and clinicians.
癌症的治疗抵抗仍然是科学家和肿瘤学家渴望解决的难题。尽管有几项专门用于克服治疗抵抗的临床前和临床研究，但它们往往没有产生预期的结果。这主要是由于治疗抵抗的多因素现象。去甲斑蝥素（NCTD）是一种人工合成的化合物，来源于斑蝥素，具有显著的抗癌疗效，而不会产生严重的副作用。有趣的是，广泛的研究表明，NCTD 对于提高抗癌疗效和逆转治疗抵抗至关重要。本文综述了 NCTD 如何有效地克服癌症对化疗、放疗、激素治疗和靶向治疗等标准治疗的抵抗。我们还讨论了使用 NCTD 作为逆转癌症治疗抵抗的治疗策略的潜在前景和挑战。我们预计，我们的综述将为研究人员和临床医生提供有价值的参考。
