Dr. Miriam and Sheldon G. Adelson Clinic for Drug Abuse, Treatment and Research, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel.
Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Harm Reduct J. 2024 Mar 1;21(1):55. doi: 10.1186/s12954-024-00970-7.
Immigrants from the former Union of Soviet Socialist Republics (USSR) are more prevalent in Methadone maintenance treatment (MMT) in Israel than their percentage in the general population.
To compare their characteristics and outcomes to those of Israeli-born and other immigrant patients.
Retention and survival since admission (June/1993-Dec/2022) until leaving treatment (for retention), or at the end of follow-up were analyzed. Vital data was taken from a national registry. Predictors were estimated using Kaplan-Meier and Cox regression models.
The USSR patients (N = 262) compared with other immigrants (N = 132) and Israeli-born (N = 696) were more educated (≥ 12y) (p < 0.001), admitted to MMT at a younger age (p < 0.001), following a shorter duration of opioid usage (p < 0.001). More of them ever injected drugs (p < 0.001) and ever drank alcohol (p < 0.001). One-year retention was comparable (77.2% vs. 75.6% and 72%, p = 0.2) as did opioid discontinuation in those who stayed (p = 0.2). Former USSR patients had longer cumulative retention of their first admission (p = 0.05) with comparable overall retention since first admission, and survival, although the age of death was younger. Specific origin within the former USSR found immigrants from the Russian Federation with the best outcome, and those from Ukraine as having high HIV seropositive and shorter retention.
Despite several characteristics known to be associated with poor outcomes, former USSR immigrants showed better adherence to MMT, reflected by their longer cumulative retention in their first admission, lower rate of readmissions, and a comparable survival and overall retention in treatment. An in depth study is needed in order to understand why they decease at a younger age.
前苏联（USSR）移民在以色列美沙酮维持治疗（MMT）中比他们在总人口中的比例更为普遍。
将他们的特征和结果与以色列出生的患者和其他移民患者进行比较。
分析自 1993 年 6 月至 2022 年 12 月入院（保留）或随访结束时离开治疗的保留和生存情况。生命数据取自国家登记处。使用 Kaplan-Meier 和 Cox 回归模型估计预测因素。
与其他移民（N=132）和以色列出生的患者（N=696）相比，前苏联患者（N=262）受教育程度更高（≥12 年）（p<0.001），接受 MMT 的年龄更小（p<0.001），使用阿片类药物的时间更短（p<0.001）。更多的人曾经注射过毒品（p<0.001）和曾经饮酒（p<0.001）。一年的保留率相当（77.2%比 75.6%和 72%，p=0.2），保持的患者停止使用阿片类药物的情况也相当（p=0.2）。前苏联患者首次入院的累积保留时间更长（p=0.05），自首次入院以来的总体保留时间和生存时间相当，尽管死亡年龄更小。在前苏联，来自俄罗斯联邦的移民具有最好的结果，而来自乌克兰的移民具有较高的 HIV 阳性率和较短的保留率。
尽管存在一些已知与不良结局相关的特征，但前苏联移民对 MMT 的依从性更好，这反映在他们首次入院的累积保留时间更长、再入院率更低，以及在治疗中的生存和总体保留时间相当。需要进行深入研究，以了解他们为何在年轻时死亡。
