Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
Mol Biol Rep. 2024 Mar 2;51(1):382. doi: 10.1007/s11033-024-09212-2.
Gentamicin leads to nephrotoxicity with increasing oxidative stress. In the present research the role of citronellol on oxidative damage induced by gentamicin in nephrotoxic rats was evaluated.
Forty-twomale Wistar rats were randomly divided into seven equal groups; healthy control, gentamicin, DMSO, citronellol 50, citronellol 100, citronellol 200 and vitamin E. The animals were anesthetized after 12 days of treatment. Kidney and serum samples were received for biochemical, histological changes, and gene expression assessments. The levels of serum glutathione (GSH), serum and kidney glutathione peroxidase (GPX) and the expression of GPX gene against gentamicin group were increased in citronellol treatment groups. The levels of serum and kidney malondialdehyde (MDA), urine protein, serum creatinine and the gene expression of inflammatory factors including tumor necrosis factor-alpha (TNF-α) and Interleukin 6 (IL-6) against gentamicin group were decreased in these groups. Moreover, recuperation in histological alterations was shown in three groups receiving citronellol compared to the gentamicin group.
Citronellol with its antioxidant and anti-inflammatory properties can decrease kidney damage caused by nephrotoxicity induced by gentamicin.
庆大霉素可导致肾毒性，并增加氧化应激。本研究旨在评估香茅醇在庆大霉素致肾毒性大鼠氧化损伤中的作用。
42 只雄性 Wistar 大鼠随机分为 7 组：健康对照组、庆大霉素组、DMSO 组、香茅醇 50 组、香茅醇 100 组、香茅醇 200 组和维生素 E 组。治疗 12 天后，对动物进行麻醉。收集肾脏和血清样本，进行生化、组织学变化和基因表达评估。与庆大霉素组相比，香茅醇治疗组的血清谷胱甘肽（GSH）、血清和肾脏谷胱甘肽过氧化物酶（GPX）水平以及 GPX 基因的表达均增加。与庆大霉素组相比，这些组的血清和肾脏丙二醛（MDA）、尿蛋白、血清肌酐和肿瘤坏死因子-α（TNF-α）和白细胞介素 6（IL-6）等炎症因子的基因表达均降低。此外，与庆大霉素组相比，三组香茅醇治疗组的组织学改变得到恢复。
香茅醇具有抗氧化和抗炎特性，可减轻庆大霉素引起的肾毒性导致的肾脏损伤。
