Department of Gynecology, Fujian Provincial Geriatric Hospital, Fuzhou 350003, Fujian Province, China; The First Clinical College of Fujian Medical University, Fuzhou 350004, Fujian Province, China.
The First Clinical College of Fujian Medical University, Fuzhou 350004, Fujian Province, China.
Eur J Obstet Gynecol Reprod Biol. 2024 May;296:120-125. doi: 10.1016/j.ejogrb.2024.02.034. Epub 2024 Feb 20.
Endometriosis is a common gynecological disease among women of reproductive age. It is a chronic estrogen and progestin related inflammatory disease. At present, the main treatments for endometriosis are drug therapy and surgery. In drug therapy, progesterone is listed as the first-line recommendation in multinational guidelines. Dydrogesterone, as an oral reversal progesterone, can slow down the metabolism of progesterone, inhibit angiogenesis and extracellular matrix degradation to inhibit the proliferation of the ectopic endometrium, induce the atrophy of the ectopic endometrium through the pro-apoptotic pathway, and treat endometriosis through multiple mechanisms of regulating inflammatory factors to reduce inflammation. Clinically, dydrogesterone treatment of endometriosis can relieve patients' symptoms, promote fertility, be used in combination, and is safe. This article will review the mechanism and clinical application of dydrogesterone in the treatment of endometriosis.
子宫内膜异位症是生育年龄妇女的常见妇科疾病，是一种慢性雌激素和孕激素相关的炎症性疾病。目前，子宫内膜异位症的主要治疗方法是药物治疗和手术治疗。在药物治疗中，孕激素被列为多国指南的一线推荐。地屈孕酮作为一种口服孕激素逆转剂，可减缓孕激素的代谢，抑制血管生成和细胞外基质降解，从而抑制异位内膜的增殖，通过促凋亡途径诱导异位内膜萎缩，并通过调节炎症因子来治疗子宫内膜异位症，从而减轻炎症。临床上，地屈孕酮治疗子宫内膜异位症可以缓解患者的症状，提高生育能力，联合应用安全。本文将综述地屈孕酮治疗子宫内膜异位症的作用机制及临床应用。
