School of Sport Science, Beijing Sport University, 48 Xinxi Road, Beijing 100084, China; Laboratory of Sports Stress and Adaptation of General Administration of Sports, 48 Xinxi Road, Beijing 100084, China.
School of Sport Science, Beijing Sport University, 48 Xinxi Road, Beijing 100084, China.
Arch Gerontol Geriatr. 2024 Jun;121:105364. doi: 10.1016/j.archger.2024.105364. Epub 2024 Feb 5.
Chronic diseases such as chronic obstructive pulmonary disease (COPD) have been linked to low levels of physical activity (PA) and higher frequency of leisure sedentary behavior (LSB). The main causes of COPD include respiratory and peripheral muscle dysfunction, low levels of PA, and LSB which are associated with a higher risk of developing COPD. The attribution relationship between PA or LSB and COPD risk or COPD respiratory insufficiency is unclear. To explore this further, we conducted a Mendelian randomization (MR) study using a genotype-simulated randomized trial group to systematically evaluate the causal relationships of PA/LSB on COPD risk and respiratory insufficiency.
The exposure data were obtained from large-scale genome-wide association studies (GWAS), including the PA dataset (N = 729,373) and LSB dataset (N = 1,109,337). The outcome data were derived from the Finn-Gen COPD dataset (N = 381,392). The causal effects were estimated with IVW, MR-Egger, and WM. Sensitivity analysis was conducted using Cochran's Q test, MR-Egger intercept test, MR-PRESSO, leave-one-out analysis, and funnel plot to estimate the robustness of our findings.
Genetically predicted leisure television (TV) watching significantly increased the risk of COPD (OR = 2.4895, 95 % CI: 1.85259 to 3.34536; P = 1.44 × 10) and COPD respiratory insufficiency (OR = 2.55, 95 % CI: 1.53 to 4.27; P = 3.54 × 10). No casual effect of other PA or LSB phenotypes on COPD risk or respiratory insufficiency was observed.
Our study provides evidence that TV watching may increase the risk of COPD and its related respiratory insufficiency. These findings emphasized the importance of promoting regular physical exercise and reducing leisure sedentary behavior to prevent COPD.
慢性疾病，如慢性阻塞性肺疾病（COPD），与低水平的身体活动（PA）和更高频率的休闲久坐行为（LSB）有关。COPD 的主要病因包括呼吸和外周肌肉功能障碍、低水平的 PA 和 LSB，这些因素与更高的 COPD 发病风险相关。PA 或 LSB 与 COPD 风险或 COPD 呼吸功能不全之间的归因关系尚不清楚。为了进一步探讨这个问题，我们使用基于基因型的模拟随机试验组进行了孟德尔随机化（MR）研究，以系统评估 PA/LSB 对 COPD 风险和呼吸功能不全的因果关系。
暴露数据来自大规模全基因组关联研究（GWAS），包括 PA 数据集（N=729373）和 LSB 数据集（N=1109337）。结果数据来自芬兰 COPD 数据集（N=381392）。使用 IVW、MR-Egger 和 WM 估计因果效应。使用 Cochran's Q 检验、MR-Egger 截距检验、MR-PRESSO、逐一剔除分析和漏斗图进行敏感性分析，以评估我们研究结果的稳健性。
遗传预测的休闲电视（TV）观看显著增加了 COPD 的发病风险（OR=2.4895，95%CI：1.85259 至 3.34536；P=1.44×10）和 COPD 呼吸功能不全（OR=2.55，95%CI：1.53 至 4.27；P=3.54×10）。其他 PA 或 LSB 表型对 COPD 风险或呼吸功能不全无因果影响。
本研究提供了证据表明，看电视可能会增加 COPD 及其相关呼吸功能不全的发病风险。这些发现强调了促进有规律的身体活动和减少休闲久坐行为以预防 COPD 的重要性。
