环孢素A、地塞米松和苯扎氯铵（BAK）对兔和豚鼠眼角膜上皮伤口愈合的影响。
Influence of cyclosporin A, dexamethasone, and benzalkonium chloride (BAK) on corneal epithelial wound healing in the rabbit and guinea pig eye.
作者信息
Kössendrup D, Wiederholt M, Hoffmann F
出版信息
Cornea. 1985;4(3):177-81.
Corneal erosions were produced by iodine vapor application in rabbit and guinea pig eyes. The corneal erosion of each eye was photographed four times daily after fluorescein staining and the erosion area measured planimetrically. Thirty-six percent of the corneal epithelium was destroyed in rabbits and 67% in guinea pigs. In guinea pigs, wound healing was delayed significantly by Spersadex, Totocortin, and benzalkonium chloride (BAK) 0.01% in the experimental eye. Spersadex also caused a significant delay in wound healing in the nontreated contralateral eye. Cyclosporin A 2% and Oculotect had no influence on epithelial wound healing. An 8-day pretreatment of guinea pig eyes with cyclosporin A or Spersadex had no further influence on the epithelial wound-healing rate.
通过向兔眼和豚鼠眼施加碘蒸汽造成角膜糜烂。荧光素染色后，每天对每只眼睛的角膜糜烂情况拍照4次，并采用面积测量法测量糜烂面积。兔角膜上皮有36%被破坏，豚鼠为67%。在豚鼠中，实验眼使用斯佩萨德克斯（Spersadex）、托托考汀（Totocortin）和0.01%苯扎氯铵（BAK）会显著延迟伤口愈合。斯佩萨德克斯在未处理的对侧眼也导致伤口愈合显著延迟。2%环孢素A和奥库洛泰克（Oculotect）对上皮伤口愈合无影响。豚鼠眼用环孢素A或斯佩萨德克斯进行8天预处理对上皮伤口愈合率没有进一步影响。
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