下肢溃疡是镰状细胞病患者全身功能障碍的指标。
Leg ulcers are indicators of systemic dysfunction in individuals with sickle cell disease.
机构信息
Health Disparities Unit, Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, Maryland, USA.
Department of Medicine, Einstein College of Medicine, Bronx, New York, USA.
出版信息
Am J Hematol. 2024 Apr;99(4):767-769. doi: 10.1002/ajh.27250. Epub 2024 Mar 3.
Abstract
Leg ulcers in individuals living with Sickle Cell Disease are evidence of systemic dysfunction. Data from a U.S. study link leg ulcers to wider pulse pressure and markers of chronic hemolysis, inflammation, renal, and liver dysfunction.
摘要
镰状细胞病患者的腿部溃疡表明全身功能紊乱。美国一项研究的数据表明，腿部溃疡与更广泛的脉压以及慢性溶血、炎症、肾功能和肝功能障碍的标志物有关。
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本文引用的文献
1
Elevated pulse pressure is associated with hemolysis, proteinuria and chronic kidney disease in sickle cell disease.在镰状细胞病中，脉压升高与溶血、蛋白尿及慢性肾脏病相关。
PLoS One. 2014 Dec 5;9(12):e114309. doi: 10.1371/journal.pone.0114309. eCollection 2014.
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The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe.美国和欧洲 415 例镰状细胞贫血患者的溶血严重程度、临床表现与死亡风险之间的关系。
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Laboratory and echocardiography markers in sickle cell patients with leg ulcers.镰状细胞病患者下肢溃疡的实验室和超声心动图标志物。
Am J Hematol. 2011 Aug;86(8):705-8. doi: 10.1002/ajh.22065. Epub 2011 May 31.
4
Leg ulcers in sickle cell disease.镰状细胞病中的腿部溃疡。
Am J Hematol. 2010 Oct;85(10):831-3. doi: 10.1002/ajh.21838.
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