Beyoglu Eye Training and Research Hospital, University of Health Sciences Turkey, Istanbul, Turkey.
Curr Eye Res. 2024 Jul;49(7):717-724. doi: 10.1080/02713683.2024.2323520. Epub 2024 Mar 3.
To evaluate the microvasculature during remission in patients with pars planitis (PP-IU) and multiple sclerosis-associated intermediate uveitis (MS-IU) using optical coherence tomography angiography (OCT-A).
Single-center, descriptive, case-control study was conducted. Adult patients (≥16 years) with IU in remission (PP-IU and MS-IU) and healthy age-sex matched healthy controls (HC) were enrolled to the study. Demographic/clinical features, best-corrected visual acuity (BCVA), ocular findings, neurological symptoms and preferred treatments were recorded. The presence of cystoid macular edema (CME) during follow-up was recorded. All IU patients in remission and HC subjects were scanned with OCT-A. Foveal avascular zone (FAZ) areas of superficial and deep capillary plexus (SCP/DCP) and vascular densities of SCP, DCP and choriocapillaris were obtained from OCT-A and compared between the groups.
Sixty-nine eyes of 37 IU patients in remission and 20 HC were included (44 eyes/23 patients in PP-IU, 25/14 in MS-IU, 40/20 in HC). No statistically significant differences were observed in terms of demographic or clinical characteristics of the patients. The vascular density in the SCP was significantly reduced in the PP-IU and MS-IU groups compared to the HC group ( < .05). Nevertheless, there were no significant changes in any of the OCTA parameters between the IU groups. Uveitis duration was found to be correlated with enlargement of the FAZ area in PP-IU ( = .039).
OCTA may not be useful in differentiating between PP-IU and MS-IU. Nevertheless, the primary implication in SCP potentially elucidates the pathogenesis of these two subtypes of IU, which are characterized by a shared pathogenesis. The monitoring of the FAZ area in the PP-IU group is valuable in terms of chronicity.
使用光相干断层扫描血管造影术（OCT-A）评估中间葡萄膜炎（IU）缓解期的特发性葡萄膜炎（PP-IU）和多发性硬化相关性中间葡萄膜炎（MS-IU）患者的微血管。
进行单中心、描述性、病例对照研究。将患有 IU 缓解期（PP-IU 和 MS-IU）的成年患者（≥16 岁）和年龄、性别匹配的健康对照组（HC）纳入研究。记录人口统计学/临床特征、最佳矫正视力（BCVA）、眼部表现、神经系统症状和首选治疗方法。记录随访期间是否存在囊样黄斑水肿（CME）。所有 IU 缓解期患者和 HC 受试者均进行 OCT-A 扫描。从 OCT-A 获得浅层和深层毛细血管丛（SCP/DCP）的中心凹无血管区（FAZ）面积和 SCP、DCP 和脉络膜毛细血管的血管密度，并比较各组之间的差异。
共纳入 37 例 IU 缓解期患者的 69 只眼和 20 名 HC（44 只眼/23 例 PP-IU，25 只眼/14 例 MS-IU，40 只眼/20 例 HC）。患者的人口统计学或临床特征无统计学差异。与 HC 组相比，PP-IU 和 MS-IU 组的 SCP 血管密度明显降低（ < .05）。然而，两组之间的任何 OCTA 参数均无显著变化。发现 PP-IU 中 FAZ 面积的扩大与葡萄膜炎持续时间相关（ = .039）。
OCT-A 可能无法用于区分 PP-IU 和 MS-IU。然而，SCP 的原发性变化可能阐明了这两种 IU 亚型的发病机制，它们具有共同的发病机制。在 PP-IU 组中监测 FAZ 区域具有慢性意义。
