Liu Chen-Ling, Zhu Jing-Yi, Wang Lin-Lin, Gao Yuan, Yan Zi-Yi, Wang Jia-Yin, Liu Sheng-Jun
Graduate School,Hebei North University,Zhangjiakou,Hebei 075000,China.
Department of Nephrology,The First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2024 Feb;46(1):43-48. doi: 10.3881/j.issn.1000-503X.15731.
Objective To analyze the correlations between platelet-related parameters and the incidence of anxiety and depression in the patients undergoing peritoneal dialysis(PD),and evaluate the efficacy of the parameters in the diagnosis of anxiety and depression in PD patients. Methods A total of 245 patients undergoing PD in the First Affiliated Hospital of Hebei North University from September 2022 to February 2023 were enrolled.The generalized anxiety scale(GAD-7) and the patient health questionnaire(PHQ-9) were used to evaluate the anxiety and depression of the patients,respectively.The personal information and biochemical indicators of the patients were collected,and the platelet count(PLT),mean platelet volume(MPV),and platelet distribution width(PDW) were measured.Logistic regression was adopted to analyze the relationships of platelet-related parameters with anxiety and depression in PD patients. Results Among the 245 patients undergoing PD,the incidences of anxiety and depression were 15.9% and 38.0%,respectively.There were differences in the dialysis period(=-2.358,=0.018;=-3.079,=0.002),MPV(=-4.953,<0.001;=-7.878,<0.001),and PDW(=-4.587,<0.001;Z=-7.367,<0.001) between the anxiety group and the non-anxiety group as well as between the depression group and the non-depression group.The correlation analysis showed that MPV(=0.358,<0.001;=0.489,<0.001) and PDW(=0.340,<0.001;=0.447,<0.001) were positively correlated with anxiety and depression in the patients undergoing PD.The Logistic regression model showed that MPV(=0.022,=0.011),PDW(=0.041,=0.018),and dialysis period(=0.011,=0.030) were independent risk factors for the anxiety and depressive state in PD patients.The areas under the receiver operating characteristic curve of MPV in the diagnosis of anxiety and depression in PD patients were 0.750 and 0.800,respectively,and those of PDW were 0.732 and 0.780,respectively. Conclusion MPV and PDW have high efficacy in the diagnosis of anxiety and depression associated with PD and can be used as objective indicators to evaluate the anxiety and depression in the patients undergoing PD.
目的 分析血小板相关参数与腹膜透析（PD）患者焦虑和抑郁发生率之间的相关性，并评估这些参数在PD患者焦虑和抑郁诊断中的效能。方法 选取2022年9月至2023年2月在河北北方学院附属第一医院接受PD治疗的245例患者。分别采用广泛性焦虑量表（GAD - 7）和患者健康问卷（PHQ - 9）评估患者的焦虑和抑郁情况。收集患者的个人信息和生化指标，检测血小板计数（PLT）、平均血小板体积（MPV）和血小板分布宽度（PDW）。采用Logistic回归分析血小板相关参数与PD患者焦虑和抑郁的关系。结果 在245例PD患者中，焦虑和抑郁的发生率分别为15.9%和38.0%。焦虑组与非焦虑组、抑郁组与非抑郁组之间在透析时间（Z = - 2.358，P = 0.018；Z = - 3.079，P = 0.002）、MPV（Z = - 4.953，P < 0.001；Z = - 7.878，P < 0.001）和PDW（Z = - 4.587，P < 0.001；Z = - 7.367，P < 0.001）方面存在差异。相关性分析显示，MPV（r = 0.358，P < 0.001；r = 0.489，P < 0.001）和PDW（r = 0.340，P < 0.001；r = 0.447，P < 0.001）与PD患者的焦虑和抑郁呈正相关。Logistic回归模型显示，MPV（β = 0.022，P = 0.011）、PDW（β = 0.041，P = 0.018）和透析时间（β = 0.011，P = 0.030）是PD患者焦虑和抑郁状态的独立危险因素。MPV诊断PD患者焦虑和抑郁的受试者工作特征曲线下面积分别为0.750和0.800，PDW的分别为0.732和0.780。结论 MPV和PDW在诊断与PD相关的焦虑和抑郁方面具有较高效能，可作为评估PD患者焦虑和抑郁的客观指标。
