Lei Zi, Wang Ying-Xia, Wang Zhi-Yuan, Yang Cheng-Gang, Pan Guo-Qing
Department of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Department of Pathology, Third Affiliated Hospital of Kunming Medical University, Kunming, China.
Front Oncol. 2024 Feb 16;14:1302196. doi: 10.3389/fonc.2024.1302196. eCollection 2024.
The aim of this report was to comprehensively investigate the clinicopathological features, histological characteristics, and differential diagnosis of tall cell carcinoma with reversed polarity of the breast (TCCRP) to enhance the understanding of this tumour for precise therapeutic interventions.
The clinicopathological characteristics and differential diagnosis of a patient with TCCRP were retrospectively analysed, and a systematic literature review was extracted from relevant published studies on PubMed.
All patients included in the study were female, with a median age of 51 years. Microscopically, the tumour cells exhibited a solid papillary growth pattern with tall columnar morphology and reversed nuclear polarity. Immunohistochemistry revealed that the tumours were triple-negative breast cancer (negative for ER, PR, and HER-2), with a low Ki-67 proliferation index. Different degrees of expression were observed for CK7, Calretinin, and S-100 markers; however, CK5/6 showed high expression levels.
TCCRP is an uncommon invasive carcinoma subtype found in the breast. Its histological morphology resembles that of tall cell subtype papillary thyroid carcinoma. Accurate diagnosis requires the integration of histomorphological assessment along with immunohistochemistry and molecular genetics analysis.
本报告旨在全面研究乳腺高细胞极性反转癌（TCCRP）的临床病理特征、组织学特点及鉴别诊断，以增进对该肿瘤的认识，从而进行精准的治疗干预。
回顾性分析1例TCCRP患者的临床病理特征及鉴别诊断情况，并从PubMed上相关已发表研究中提取系统性文献综述。
纳入研究的所有患者均为女性，中位年龄51岁。镜下，肿瘤细胞呈实性乳头状生长模式，具有高柱状形态且核极性反转。免疫组化显示，这些肿瘤为三阴性乳腺癌（雌激素受体、孕激素受体和人表皮生长因子受体2均为阴性），Ki-67增殖指数较低。细胞角蛋白7、钙视网膜蛋白和S-100标记物呈现不同程度表达；然而，细胞角蛋白5/6显示高表达水平。
TCCRP是一种在乳腺中发现的罕见浸润性癌亚型。其组织形态学类似于高细胞亚型甲状腺乳头状癌。准确诊断需要结合组织形态学评估、免疫组化及分子遗传学分析。
