Fu Xiaoling, Song Yutong, Feng Xianquan, Liu Zhihong, Gao Wenhao, Song Hongtao, Zhang Qian
School of Pharmacy, Fujian Medical University, Fuzhou 350108, China.
Fuzong Clinical Medical College of Fujian Medical University, Fuzhou 350025, China.
Asian J Pharm Sci. 2024 Feb;19(1):100885. doi: 10.1016/j.ajps.2024.100885. Epub 2024 Feb 5.
Amultifunctional liposomal polydopamine nanoparticle (MPM@Lipo) was designed in this study, to combine chemotherapy, photothermal therapy (PTT) and oxygen enrichment to clear hyperproliferating inflammatory cells and improve the hypoxic microenvironment for rheumatoid arthritis (RA) treatment. MPM@Lipo significantly scavenged intracellular reactive oxygen species and relieved joint hypoxia, thus contributing to the repolarization of M1 macrophages into M2 phenotype. Furthermore, MPM@Lipo could accumulate at inflammatory joints, inhibit the production of inflammatory factors, and protect cartilage , effectively alleviating RA progression in a rat adjuvant-induced arthritis model. Moreover, upon laser irradiation, MPM@Lipo can elevate the temperature to not only significantly obliterate excessively proliferating inflammatory cells but also accelerate the production of methotrexate and oxygen, resulting in excellent RA treatment effects. Overall, the use of synergistic chemotherapy/PTT/oxygen enrichment therapy to treat RA is a powerful potential strategy.
本研究设计了一种多功能脂质体聚多巴胺纳米颗粒（MPM@Lipo），将化疗、光热疗法（PTT）和富氧相结合，以清除过度增殖的炎性细胞并改善类风湿关节炎（RA）治疗的缺氧微环境。MPM@Lipo显著清除细胞内活性氧并缓解关节缺氧，从而促进M1巨噬细胞重极化至M2表型。此外，MPM@Lipo可在炎性关节处积聚，抑制炎性因子产生并保护软骨，在大鼠佐剂性关节炎模型中有效缓解RA进展。此外，在激光照射下，MPM@Lipo可升高温度，不仅能显著消除过度增殖的炎性细胞，还能加速甲氨蝶呤和氧气的产生，从而产生优异的RA治疗效果。总体而言，采用协同化疗/PTT/富氧疗法治疗RA是一种极具潜力的策略。
