Tsoukalas Nikolaos, Tsapakidis Konstantinos, Tolia Maria, Kiakou Maria, Galanopoulos Michalis, Aravantinou-Fatorou Eleni, Baxevanos Panagiotis, Papadopoulos Vasileios, Tountziaris Chrysovalantis, Nikolaou Michalis, Kamposioras Konstantinos
Department of Oncology, 401 General Military Hospital of Athens, Athens, Greece.
Department of Radiotherapy, Faculty of Medicine, School of Health Sciences, University of Crete, Heraklion, Greece.
Cancer Diagn Progn. 2024 Mar 3;4(2):198-203. doi: 10.21873/cdp.10308. eCollection 2024 Mar-Apr.
Pseudomyxoma peritonei (PMP) is a clinical entity of subtle onset abdominal pain, ascites, and distention associated with characteristic imaging. In most cases, laparoscopic exploration will give the definitive diagnosis and histopathologic verification. However, usually there are difficulties in the diagnosis of this disease.
Herein, we present a case of a 51-year-old female who developed ascites over 5 months. An investigational laparotomy established the diagnosis of PMP, after the discovery of a mucinous, grey-brown tumor that was CK20 positive and CK7 negative. Subsequently, chemotherapy with oxaliplatin combined with 5-FU (FOLFOX4 regimen), was initiated and the patient survived for 30 months. We also present a comprehensive review of the English literature concerning the different symptoms and radiological findings of this rare entity. According to the literature review, 35 cases of PMP with different clinical and radiological findings have been described. In the majority of the cases, ultrasound, computed tomography or magnetic resonance imaging was orientating towards a proper diagnosis before a diagnostic laparotomy.
The combination of a clinical picture with the characteristic imaging findings enables a prompt diagnosis of PMP, making prognosis more favorable.
腹膜假黏液瘤（PMP）是一种临床病症，表现为隐匿起病的腹痛、腹水和腹胀，并伴有特征性影像学表现。在大多数情况下，腹腔镜探查可做出明确诊断并进行组织病理学验证。然而，该疾病的诊断通常存在困难。
在此，我们报告一例51岁女性患者，其腹水持续5个月。在发现一个CK20阳性、CK7阴性的黏液性、灰棕色肿瘤后，经剖腹探查确诊为PMP。随后，患者开始接受奥沙利铂联合5-氟尿嘧啶的化疗（FOLFOX4方案），存活了30个月。我们还对有关该罕见病症不同症状和影像学表现的英文文献进行了全面综述。根据文献综述，已描述了35例具有不同临床和影像学表现的PMP病例。在大多数病例中，超声、计算机断层扫描或磁共振成像在诊断性剖腹探查前有助于做出正确诊断。
临床表现与特征性影像学表现相结合能够迅速诊断PMP，使预后更有利。
