Wang Lixin, Chen Gang, Jiang Jingui, Liu Guoyan, Tuo Ying-Lan, Li Xiaohong, Zhang Weishan
Department of Pathology, Jinhu County People's Hospital, Huaian City, People's Republic of China.
Department of Gynecology, Jinhu County People's Hospital, Huaian City, People's Republic of China.
Int J Gen Med. 2024 Feb 26;17:663-667. doi: 10.2147/IJGM.S449102. eCollection 2024.
This study examines the clinical and pathological characteristics, immune profile, histological occurrence, diagnosis, and differential diagnosis of vulvar hidradenoma papilliferum.
An analysis was conducted on clinical data, histological patterns, and immunohistochemical findings from 45 cases of vulvar hidradenoma papilliferum, and relevant published articles were reviewed. Simultaneously, high-risk HPV typing was performed on these 45 cases.
The 45 cases of vulvar hidradenoma papilliferum displayed tumor sizes ranging from 0.3 to 2.0 cm and were observed to be pink or red in appearance. Vacuolated cytoplasm, large abnormal nuclei, distinct nucleoli, and scattered eosinophilic luminal secretions were observed in the glands. Positive staining for CK7 and progesterone receptor (PR) with focal mammaglobin and GCDFP-15 expression was found through immunohistochemistry. CK20 staining was noted as negative.
Hidradenoma papilliferum is a rare benign tumor that originates in secretory glands. The diagnosis of this condition is aided by gross and immunohistochemical results, and differentiation from other conditions is necessary.
本研究探讨乳头汗腺瘤的临床及病理特征、免疫表型、组织学发生、诊断及鉴别诊断。
对45例乳头汗腺瘤的临床资料、组织学形态及免疫组化结果进行分析，并复习相关文献。同时，对这45例进行高危型人乳头瘤病毒（HPV）分型检测。
45例乳头汗腺瘤肿瘤大小为0.3至2.0cm，外观呈粉红色或红色。腺体可见空泡状细胞质、大的异形核、明显的核仁及散在的嗜酸性管腔分泌物。免疫组化显示细胞角蛋白7（CK7）和孕激素受体（PR）呈阳性染色，局灶性乳腺珠蛋白和巨囊性病液体蛋白15（GCDFP-15）表达阳性。细胞角蛋白20（CK20）染色为阴性。
乳头汗腺瘤是一种罕见的起源于分泌腺的良性肿瘤。大体及免疫组化结果有助于本病的诊断，且有必要与其他疾病相鉴别。
