Nizami Awais Ahmed, Mustafa Waqar, Qadir Mamoon, Shahzad Maria, Iqbal Hamid, Ali Anwar, Jadoon Sarosh Khan, Akbar Amna, Tasneem Sabahat, Saleem Khan Mohammad
Cath Lab, Shahida Islam Medical College, Lodhran, PAK.
Cardiology, Combined Military Hospital, Muzaffarabad, PAK.
Cureus. 2024 Feb 1;16(2):e53411. doi: 10.7759/cureus.53411. eCollection 2024 Feb.
This study aimed to investigate the risk factors associated with major adverse cardiovascular (group of events that affect heart and blood vessels) and cerebrovascular (events affecting blood vessels supplying the brain) events (MACCE) in patients with uraemia complicated with hypertension who required maintenance haemodialysis (MHD) treatment.
Clinical data and laboratory indicators of 156 uraemia patients complicated with hypertension were collected and retrospectively analysed. The patients were admitted to a tertiary care hospital (Abbas Institute of Medical Sciences AIMS) in Muzaffarabad, Pakistan, from February 2018 to February 2022. The data was collected through consecutive sampling and patients were recruited after following the inclusion and exclusion criteria.
Eighty-one out of 156 patients were not complicated with MACCE, and 75 patients were complicated with MACCE during the MHD treatment cycle, with an incidence of 48.08%. Compared to the non-MACCE group, the MACCE group's diabetes, body mass growth rate, triglyceride (TG), NT-proBNP, standard deviation and coefficient of variance for systolic and diastolic blood pressure (SBP-SD, SBP-CV, DBP-SD, and DBP-CV) showed significant differences (P<0.05) between the groups. Diabetes, body mass growth rate, TG, NT-proBNP, SBP-SD, SBP-CV, DBP-SD, and DBP-CV with odds ratios of 3.074, 3.202, 2.188, 2.512, 2.357, 2.431, 2.299, and 2.062 respectively were risk factors for MACCE in uraemia patients with hypertension.
From the results of this study, we inferred that patients with uraemia and hypertension complicated by MACCE in the treatment cycle of MHD were related to diabetes, body mass growth rate, TG, NT-proBNP, SBP-SD, SBP-CV, DBP-SD, and DBP-CV.
本研究旨在调查需要维持性血液透析（MHD）治疗的尿毒症合并高血压患者发生主要不良心血管（影响心脏和血管的一组事件）和脑血管（影响供应大脑血管的事件）事件（MACCE）的相关危险因素。
收集156例尿毒症合并高血压患者的临床资料和实验室指标，并进行回顾性分析。这些患者于2018年2月至2022年2月入住巴基斯坦穆扎法拉巴德的一家三级护理医院（阿巴斯医学科学研究所AIMS）。数据通过连续抽样收集，患者在遵循纳入和排除标准后被招募。
156例患者中有81例在MHD治疗周期中未发生MACCE，75例发生MACCE，发生率为48.08%。与非MACCE组相比，MACCE组的糖尿病、体重增长率、甘油三酯（TG）、NT-proBNP、收缩压和舒张压的标准差及变异系数（SBP-SD、SBP-CV、DBP-SD和DBP-CV）在组间显示出显著差异（P<0.05）。糖尿病、体重增长率、TG、NT-proBNP、SBP-SD、SBP-CV、DBP-SD和DBP-CV的比值比分别为3.074、3.202、2.188、2.512、2.357、2.431、2.299和2.062，是尿毒症合并高血压患者发生MACCE的危险因素。
从本研究结果推断，在MHD治疗周期中发生MACCE的尿毒症合并高血压患者与糖尿病、体重增长率、TG、NT-proBNP、SBP-SD、SBP-CV、DBP-SD和DBP-CV有关。
