Orzechowska-Wylęgała Bogusława, Wylęgała Adam, Zalejska Fiolka Jolanta, Czuba Zenon, Toborek Michal
Department of Pediatric Otolaryngology, Head and Neck Surgery, Chair of Pediatric Surgery, Medical University of Silesia (SUM), Katowice, Poland.
Health Promotion and Obesity Management, Department of Pathophysiology in Katowice, SUM, Katowice, Poland.
Pediatric Health Med Ther. 2024 Feb 27;15:95-102. doi: 10.2147/PHMT.S440223. eCollection 2024.
Saliva contains various proteins that are important in developing inflammatory processes and their prevention. One key aspect of saliva research is the relationship between oral infections and inflammation, and the role of some salivary proteins.
To demonstrate which salivary cytokines can be biomarkers of acute odontogenic oral and facial infections in children.
The study included two groups of patients: a study group of 28 children: 7 girls and 21 boys aged 3 -17 years with acute dentofacial inflammation (DI) and a control group of 52 children: 16 girls and 36 boys aged 4-17 years with uncomplicated dental caries (CE). The levels of Interleukin-5 (IL-5), Interleukin -10 (IL-10), Interleukin-17A (IL-17A), Interleukin-12p70 (IL-12p70), Eotaxin, Rantes, Vascular Endothelial Growth Factor (VEGF), and Interferon gamma-induced protein 10 (IP10) in the saliva of children in DI and CE groups were compared. Statistical analysis was performed with Statistica 13. The Student's -test and the Wilcoxon signed-rank test were used.
The results show that IL-10, IL-17A, and Eotaxin showed a statistically significant increase in the DI group compared to the CE group. The significance level for IL-10 was p=0.02, for IL-17A was equal to Eotaxin and p=0.04. The other measured parameters did not differ statistically significant between the two groups.
IL-10, IL-17A, and Eotaxin can be used as potential biomarkers for tooth-related inflammatory states of the oral cavity and face in children. These biomarkers can be useful in identifying and monitoring the presence of inflammation in the oral cavity and face.
唾液含有多种在炎症过程发展及其预防中起重要作用的蛋白质。唾液研究的一个关键方面是口腔感染与炎症之间的关系以及某些唾液蛋白的作用。
证明哪些唾液细胞因子可作为儿童急性牙源性口腔和面部感染的生物标志物。
该研究包括两组患者：一组为28名儿童的研究组，其中7名女孩和21名男孩，年龄在3至17岁，患有急性牙面部炎症（DI）；另一组为52名儿童的对照组，其中16名女孩和36名男孩，年龄在4至17岁，患有单纯性龋齿（CE）。比较了DI组和CE组儿童唾液中白细胞介素-5（IL-5）、白细胞介素-10（IL-10）、白细胞介素-17A（IL-17A）、白细胞介素-12p70（IL-12p70）、嗜酸性粒细胞趋化因子、调节激活正常T细胞表达和分泌因子（RANTES）、血管内皮生长因子（VEGF）以及干扰素γ诱导蛋白10（IP10）的水平。使用Statistica 13进行统计分析。采用学生t检验和威尔科克森符号秩检验。
结果表明，与CE组相比，DI组中IL-10、IL-17A和嗜酸性粒细胞趋化因子有统计学显著升高。IL-10的显著性水平为p = 0.02，IL-17A与嗜酸性粒细胞趋化因子相同，p = 0.04。两组之间其他测量参数无统计学显著差异。
IL-10、IL-17A和嗜酸性粒细胞趋化因子可作为儿童口腔和面部与牙齿相关炎症状态的潜在生物标志物。这些生物标志物有助于识别和监测口腔和面部炎症的存在。
